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环嗪酮

环嗪酮用途

Hexazinone 是三嗪家族的非选择性除草剂 (herbicide)。Hexazinone 与光系统 II 电子传递链的 D-1 醌蛋白结合,抑制光合作用。

环嗪酮名称

[ CAS 号 ]:
51235-04-2

[ 中文名 ]:
环嗪酮

[ 英文名 ]:
Hexazinone

[中文别名 ]:

[英文别名 ]:

Velpar
DPX A 3674
Velpar L
MFCD00055526
Gridball
EINECS 257-074-4
Velpar weed killer
Brush Killer
Caswell No. 271AA
HEXAZINONE

环嗪酮生物活性

[ 描述 ]:

Hexazinone 是三嗪家族的非选择性除草剂 (herbicide)。Hexazinone 与光系统 II 电子传递链的 D-1 醌蛋白结合,抑制光合作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Hexazinone.From Wikipedia

环嗪酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
332.8±25.0 °C at 760 mmHg

[ 熔点 ]:
97-100.5ºC

[ 分子式 ]:
C₁₂H₂₀N₄O₂

[ 分子量 ]:
252.313

[ 闪点 ]:
155.1±23.2 °C

[ 精确质量 ]:
252.158630

[ PSA ]:
60.13000

[ LogP ]:
1.85

[ 外观性状 ]:
黄褐色,自由流动颗粒带有一种淡刺鼻的气味

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

环嗪酮MSDS

环嗪酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY7850000

CHEMICAL NAME :: s-Triazine-2,4(1H,3H)-dione, 3-cyclohexyl-6-(dimethylamino)-1-methyl-

CAS REGISTRY NUMBER :: 51235-04-2

BEILSTEIN REFERENCE NO. :: 0618801

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C12-H20-N4-O2

MOLECULAR WEIGHT :: 252.36

WISWESSER LINE NOTATION :: T6NVNVNJ A1 FN1&1 C- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,603,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 2,135,1977

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7480 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A228,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5278 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C163,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 530 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,603,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5278 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,472,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972- Volume(issue)/page/year: 9,21,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 2258 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,881,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 2258 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,603,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 219 mg/kg/2Y-C

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - changes in lung weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,960,1984 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 51700 mg/kg

SEX/DURATION :: male 94 day(s) pre-mating female 94 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,960,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

环嗪酮安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301-H311-H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S60-S61

[ 危险品运输编码 ]:
UN3077 9/PG 3

[ RTECS号 ]:
XY7850000

[ 海关编码 ]:
2933699014

环嗪酮合成路线

环嗪酮上下游产品

环嗪酮上游产品

环嗪酮下游产品

环嗪酮制备

制备方法一
甲基物的合成在石灰氮与水作用，生成氰胺。滴加氯甲酸乙酯，保持反应温度40℃左右，当pH值6～7时为反应终点，滴结于40℃搅拌1h，过滤，得N-氰基-N-甲基氨基甲酸乙酯。
胍的合成上述甲基物（含量60%～80%）、二甲胺盐酸盐和水，于80～100℃反应6h，冷却，加生活方式液碱，用氯仿萃取，废水去处理工序，萃取液脱溶后得N-乙氧基羰基-N，N'，N'-三甲基胍盐酸盐，进而与碱反应生成胍。
加成物的合成在甲苯存在下，将异氰酸环己酯甲苯溶液（含量10%～20%）滴加到胍-甲苯溶液中，于50～80℃反应2h，得N-（N'-环己基氨基甲酰基-N，N-二甲脒基）-N-甲基氨基甲酸乙酯。
环嗪酮的合成将上述加成物中加入20%左右的甲醇钠进行环合得环嗪酮。环合产物需水洗、分层、脱溶、结晶、分离、干燥等后处理，得到含量≥90%的产品。
制备方法二

环嗪酮海关

[ 海关编码 ]: 2933699014

[ 中文概述 ]:
HS: 2933699014 丁嗪草酮,环嗪酮,嗪草酮等〔包括苯嗪草酮,乙嗪草酮〕增值税率:17.0% 退税率:9.0% 监管条件:S(进出口农药登记证明) 最低关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933699014 4-amino-6-(tert-butyl)-3-(methylthio)-1,2,4-triazin-5(4h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

环嗪酮文献

The interaction between natural organic matter in raw waters and pesticide residues: a three dimensional excitation-emission matrix (3DEEM) fluorescence investigation.

Water Sci. Technol. 67(11) , 2428-36, (2013)

This paper examines the interaction between dissolved natural organic matter and pesticide residues, both of which are found in raw water sources, using three dimensional excitation-emission matrix (3...

Dissipation of four forest-use herbicides at high latitudes.

Environ. Sci. Pollut. Res. Int. 15(7) , 573-83, (2008)

Large-scale deforestation is occurring in subarctic North America following clearing by salvage logging or insect attack. Numerous shrubs, herbs, and deciduous tree species tend to dominate areas on w...

Comparison between the short-term and the long-term toxicity of six triazine herbicides on photobacteria Q67

Water Res. 43(6) , 1731-9, (2009)

The bioluminescence inhibition of six triazine herbicides including desmetryne (DES), simetryn (SIM), velpar (VEL), prometon (PRO), metribuzin (MET), and aminotriazine (AMI) on Vibrio qinghaiensis sp....

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环嗪酮