硫酸妥布霉素
硫酸妥布霉素用途
Tobramycin sulfate (Nebramycin Factor 6 sulfate) 是一种胃肠外给药的广谱氨基糖苷类抗生素,已广泛用于治疗由于敏感生物引起的中度至重度细菌感染。
硫酸妥布霉素名称
[ CAS 号 ]:
49842-07-1
[ 中文名 ]:
硫酸妥布霉素
[ 英文名 ]:
Dicon
[中文别名 ]:
[英文别名 ]:
- Tobra
- 1-Epitobramycin sulfate
- Tobra Gobens
- Tomycin
- EINECS 256-499-2
- Dicon
- Egyt 341
- Obracine
- EINECS 244-922-3
- Dartobcin
硫酸妥布霉素生物活性
硫酸妥布霉素物理化学性质
[ 密度 ]:
1.52g/cm3
[ 沸点 ]:
775.4ºC at 760mmHg
[ 分子式 ]:
C18H37N5O9.5/2H2O4S
[ 分子量 ]:
565.593
[ 闪点 ]:
422.8ºC
[ 精确质量 ]:
565.226501
[ PSA ]:
351.15000
[ 外观性状 ]:
粉末
[ 储存条件 ]:
2-8°C
硫酸妥布霉素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WK2110000
- CHEMICAL NAME :
- Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6 -diamino-2,3,6-trideo xy- alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-, D-, sulfate (salt)
- CAS REGISTRY NUMBER :
- 49842-07-1
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C18-H37-N5-O9.xH2-O4-S
- MOLECULAR WEIGHT :
- 1154.16
- WISWESSER LINE NOTATION :
- T6OTJ B1Q CQ DZ EQ FO- BL6TJ AZ CQ EZ DO- BT6OTJ CZ EQ F1Z &..H2.S-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 15 mg/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - wakefulness Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 247,1319,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1680 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,60,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 126 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,60,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,60,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 262 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,60,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 560 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,60,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 77 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,60,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg/8D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - changes in adrenal weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,60,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 8400 mg/kg/30W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Behavioral - altered sleep time (including change in righting reflex) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 77,479,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1400 mg/kg/14D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - changes in cochlear structure or function
- REFERENCE :
- LARYA8 Laryngoscope. (Laryngoscope Co., 9216 Clayton Rd., Suite 18, St. Louis, MO 63124) V.1- 1896- Volume(issue)/page/year: 86,259,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1400 mg/kg/7D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - changes in cochlear structure or function
- REFERENCE :
- LARYA8 Laryngoscope. (Laryngoscope Co., 9216 Clayton Rd., Suite 18, St. Louis, MO 63124) V.1- 1896- Volume(issue)/page/year: 86,259,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4326 No. of Facilities: 305 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 21896 (estimated) No. of Female Employees: 17672 (estimated)
硫酸妥布霉素安全信息
[ 危害码 (欧洲) ]:
T: Toxic;
[ 风险声明 (欧洲) ]:
R61
[ 安全声明 (欧洲) ]:
53-22-36/37/39-45
[ WGK德国 ]:
3
相关药品：
推荐生产厂家/供应商：
公司名：上海脉铂医药科技有限公司
区域：上海市嘉定区
价格：
￥409.0/50mg
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：李先生
产品详情：Tobramycin Sulfate
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥226.9/25mg
￥514.9/100mg
￥2040.9/1g
￥1029.9/250mg
联系人：阿拉丁李高志
产品详情：硫酸妥布霉素
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥1376.0/25mg
￥374.0/5mg
￥411.6/50mg
联系人：夏言
公司名：上海陌孚医药科技有限公司
区域：上海市嘉定区
价格：
￥370.44/50mg
联系人：朱经理
产品详情：Tobramycin Sulfate
查看所有供应商请点击：
相关化合物
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