柠康酸
柠康酸用途
柠康酸名称
[ CAS 号 ]:
498-23-7
[ 中文名 ]:
柠康酸
[ 英文名 ]:
Citraconic acid
[中文别名 ]:
[英文别名 ]:
- EINECS 207-858-7
- Maleic acid,methyl
- cis-2-methylbutenedioic acid
- 2-Methylmaleic acid
- Citraconicacid
- Kyselina citrakonova
- methyl-maleicaci
- METHYLMALEIC ACID
- Citraconic acid
- 2-methyl-2-butenedioic acid
柠康酸生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[参考文献]
[相关活性小分子]
柠康酸物理化学性质
[ 密度 ]:
1,62 g/cm3
[ 沸点 ]:
336ºC
[ 熔点 ]:
88-94 °C(lit.)
[ 分子式 ]:
C5H6O4
[ 分子量 ]:
130.09900
[ 精确质量 ]:
130.02700
[ PSA ]:
74.60000
[ LogP ]:
0.10190
[ 外观性状 ]:
吸湿的,灰白色粉末
[ 蒸汽压 ]:
2.09E-05mmHg at 25°C
[ 储存条件 ]:
室温,密封,干燥
[ 水溶解性 ]:
FREELY SOLUBLE
柠康酸MSDS
柠康酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GE6650000
- CHEMICAL NAME :
- Citraconic acid
- CAS REGISTRY NUMBER :
- 498-23-7
- BEILSTEIN REFERENCE NO. :
- 1722679
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C5-H6-O4
- MOLECULAR WEIGHT :
- 130.11
- WISWESSER LINE NOTATION :
- QVY1&U1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1320 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Gastrointestinal - ulceration or bleeding from stomach
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2260 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - other changes
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1350 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - gastritis
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
柠康酸安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R22;R36/37/38
[ 安全声明 (欧洲) ]:
S36-S37/39-S26
[ 危险品运输编码 ]:
2811
[ WGK德国 ]:
3
[ RTECS号 ]:
GE6650000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2917190090
柠康酸合成路线
柠康酸上下游产品
柠康酸上游产品
柠康酸下游产品
柠康酸制备
本品在180℃加热,与硝酸或氢氧化钾作用得中康酸;与钠汞剂作用得甲基丁二酸。由蒸馏柠檬酸而得。
柠康酸海关
[ 海关编码 ]: 2917190090
[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分
[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
柠康酸文献
Anal. Chem. 83(7) , 2705-11, (2011)
Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few inter...
The antipsoriatic agent monomethylfumarate has antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes.J. Pharmacol. Exp. Ther. 352(1) , 90-7, (2015)
Monomethylfumarate (MMF) is thought to be the bioactive ingredient of the drug Fumaderm (Biogen Idec, Cambridge, MA), licensed in Germany since 1994 for the treatment of moderate-to-severe psoriasis. ...
Effects of fumaric acid esters on blood-brain barrier tight junction proteins.Neurosci. Lett. 555 , 165-70, (2013)
The blood-brain barrier (BBB) is composed of a network of tight junctions (TJ) which interconnect cerebral endothelial cells (EC). Alterations in the TJ proteins are common in inflammatory diseases of...
相关化工产品/化学物质:
推荐生产厂家/供应商:
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥278.0/25g
¥98.0/5g
联系人:刘佳
产品详情:柠康酸
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥92.9/5g
¥926.9/100g
¥144.9/10g
¥308.9/25g
联系人:阿拉丁李高志
产品详情:柠康酸
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥72.0/5g
¥261.0/25g
¥834.0/100g
联系人:夏言
产品详情:[Perfemiker]柠康酸,99%
查看所有供应商请点击:
相关化合物
【柠康酸】化源网提供柠康酸CAS号498-23-7,柠康酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询柠康酸上化源网,专业又轻松。>>电脑版:柠康酸
标题:柠康酸_MSDS_用途_密度_柠康酸CAS号【498-23-7】_化源网 地址:https://www.chemsrc.com/amp/cas/498-23-7_1026788.html