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紫云英苷

紫云英苷用途

紫云英苷(山奈酚-3-O-葡萄糖苷)是一种黄酮类化合物,具有抗炎活性。

紫云英苷名称

[ CAS 号 ]:
480-10-4

[ 中文名 ]:
紫云英苷

[ 英文名 ]:
Astragalin

[中文别名 ]:

[英文别名 ]:

Kaempferol-3-O-D-glucopyranoside
Kaempferol-3-β-glucopyranoside
Kaempferol-3-O-glucoside
Kaempferol 3-O-β-D-glucoside
kaempferol 3-O-glucoside
Astragaloside
MFCD00075932
Kaempferol-3-O-β-D-glucopyranoside
Kaempferol-3-β-monoglucoside
Kaempferol-3-D-glucoside

紫云英苷生物活性

[ 描述 ]:

紫云英苷(山奈酚-3-O-葡萄糖苷)是一种黄酮类化合物,具有抗炎活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 黄酮类化合物

研究领域 >> 炎症/免疫

[参考文献]

[1]. Cho IH, et al. Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling. BMC Pulm Med. 2014 Jul 29;14:122.

[2]. Li F, et al. Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells. J Surg Res. 2014 Dec;192(2):573-81.

[3]. Li F, et al. Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model. Int Immunopharmacol. 2013 Oct;17(2):478-82.

[4]. Kim MS, et al. Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages. Arch Pharm Res. 2011 Dec;34(12):2101-7.

[5]. Soromou LW, et al. Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway. Biochem Biophys Res Commun. 2012 Mar 9;419(2):256-61.

[相关活性小分子]

紫云英苷物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
823.2±65.0 °C at 760 mmHg

[ 熔点 ]:
223-229ºC

[ 分子式 ]:
C₂₁H₂₀O₁₁

[ 分子量 ]:
448.377

[ 闪点 ]:
291.6±27.8 °C

[ 精确质量 ]:
448.100555

[ PSA ]:
190.28000

[ LogP ]:
1.95

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.774

[ 储存条件 ]:
?20°C

紫云英苷MSDS

紫云英苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3080000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydro xyphenyl)-

CAS REGISTRY NUMBER :: 480-10-4

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H20-O11

MOLECULAR WEIGHT :: 448.41

WISWESSER LINE NOTATION :: T66 BO EVJ CR DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

紫云英苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DJ3080000

紫云英苷合成路线

紫云英苷上下游产品

紫云英苷上游产品

紫云英苷下游产品

紫云英苷文献

Separation of patuletin-3-O-glucoside, astragalin, quercetin, kaempferol and isorhamnetin from Flaveria bidentis (L.) Kuntze by elution-pump-out high-performance counter-current chromatography.

J. Chromatogr. A. 1218(36) , 6206-11, (2011)

Flaveria bidentis (L.) Kuntze is an annual alien weed of Flaveria Juss. (Asteraceae) in China. Bioactive compounds, mainly flavonol glycosides and flavones from F. bidentis (L.) Kuntze, have been stud...

A sensitive LC-MS/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves.

J. Pharm. Biomed. Anal. 84 , 189-95, (2013)

A simple and sensitive LC-MS/MS method has been developed and validated for the determination of rutin, isoquercitrin, astragalin, quercetin, kaempferol and isorhamnetin in rat plasma using naringin a...

[Study on the chemical constituets in ethyl acetante extraction from semen litchi].

Zhong Yao Cai 35(1) , 64-6, (2012)

To study the chemical constituents in ethyl acetate extraction of Semen Litchi.The compounds were isolated and purified by column chromatography on silica gel and Sephadex LH-20 coupled with preparati...

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