<生产厂家价格>

二甲他林

二甲他林用途

Dimetacrine 是一种有用的抗抑郁药，可用于治疗各种类型的抑郁症。

二甲他林名称

[ CAS 号 ]:
4757-55-5

[ 中文名 ]:
二甲他林

[ 英文名 ]:
Dimetacrine

[英文别名 ]:

Dimetacrinum
Dimetacrinum [INN-Latin]
Dimetacrine
Dimethacrine
Dimetacrina [DCIT]
10-(8-Dimethylaminopropyl)-5,5-dimethylacridan
Dimetacrine [INN]
10-(3-Dimethylaminopropyl)-5,5-dimethylacridan
Dimetacrino
Dimethacrin

二甲他林生物活性

[ 描述 ]:

Dimetacrine 是一种有用的抗抑郁药,可用于治疗各种类型的抑郁症。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体内研究]

Dimetacrine是一种有用的抗抑郁药,可用于治疗各种类型的抑郁症。最高浓度的Dimetacrine,10μM,收缩力降低至36.5±9.1％。 0.3μm的Dimetacrine不会引起对照组收缩力的统计学显着下降。在施用Dimetacrine后静脉注射1至3mg/kg静脉注射心动过速,并且以3mg/kg iv的剂量获得最大响应。给予Dimetacrine,30 mg/kg静脉注射,导致心动过速或心动过缓导致血压骤降,然后心脏骤停。输注Dimetacrine后40分钟呼吸频率增加。输注Dimetacrine后动脉血压下降50分钟[1]。

[动物实验]

使用体重8至13kg的成年雄性杂种狗并用戊巴比妥钠麻醉，35mg / kg iv通过放置在胸腹区域周围的手风琴式呼吸描记器和压力传感器测量呼吸运动。对于单次静脉注射的实验，增加剂量的Dimetacrine，0.1,0.3,1,3,10和30 mg / kg静脉注射，直到心脏骤停发生，进入空心管左侧头静脉并用1 mL冲洗。生理盐水。 IMP，AMT和Dimetacrine对每种剂量引起的动脉血压和心率的变化进行了估计[1]。

[参考文献]

[1]. Kato H, et al. Comparison of cardiovascular toxicities induced by dimetacrine, imipramine and amitriptyline in isolated guinea pig atria and anesthetized dogs. Jpn J Pharmacol. 1974 Dec;24(6):885-91.

[相关活性小分子]

二甲他林物理化学性质

[ 密度 ]:
1.015 g/cm3

[ 沸点 ]:
406.4ºC at 760mmHg

[ 分子式 ]:
C₂₀H₂₆N₂

[ 分子量 ]:
294.43400

[ 闪点 ]:
180.4ºC

[ 精确质量 ]:
294.21000

[ PSA ]:
6.48000

[ LogP ]:
4.48070

[ 折射率 ]:
1.559

[ 储存条件 ]:
2-8℃

二甲他林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR6973200

CHEMICAL NAME :: Acridan, 9,9-dimethyl-10-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 4757-55-5

BEILSTEIN REFERENCE NO. :: 1349663

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C20-H26-N2

MOLECULAR WEIGHT :: 294.48

WISWESSER LINE NOTATION :: T C666 BM IHJ B3 M1&1 I1 I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1076 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1293 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 206 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 676 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/13W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,949,1974 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 91 mg/kg

SEX/DURATION :: male 91 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,949,1974

二甲他林安全信息

[ 海关编码 ]:
2942000000

二甲他林海关

[ 海关编码 ]: 2942000000