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甘氨石胆酸

甘氨石胆酸用途

甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸。糖石胆酸可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。

甘氨石胆酸名称

[ CAS 号 ]:
474-74-8

[ 中文名 ]:
甘氨石胆酸

[ 英文名 ]:
Glycolithocholic acid

[英文别名 ]:

Glycolithocholic acid
Lithocholic acid glycine conjugate
Lithocholylglycine
Glycolithocholate

甘氨石胆酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[体内研究]

溃疡性结肠炎(UC)患者的糖石胆酸浓度显著低于健康对照组(HCs)[2]。

[参考文献]

[1]. Tanno N, et, al. Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci. 1994 Jul;39(7):1586-91.

[2]. Ang ZH, et, al. Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis. World J Gastroenterol. 2021 Jun 28;27(24):3609-3629.

[3]. Bansal S, et, al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites. J Pharmacol Exp Ther. 2019 Jun;369(3):389-405.

[4]. Sanyal AJ, et, al. Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases. JHEP Rep. 2021 Feb 19;3(3):100255.

甘氨石胆酸物理化学性质

[ 密度 ]:
1.112g/cm3

[ 沸点 ]:
619.7ºC at 760mmHg

[ 熔点 ]:
212-214°C (lit.)

[ 分子式 ]:
C₂₆H₄₃NO₄

[ 分子量 ]:
433.62400

[ 闪点 ]:
328.6ºC

[ 精确质量 ]:
433.31900

[ PSA ]:
86.63000

[ LogP ]:
5.01420

[ 储存条件 ]:
2-8°C

甘氨石胆酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0594200

CHEMICAL NAME :: Glycine, N-((3-alpha,5-beta)-3-hydroxy-24-oxocholan-24-yl)-

CAS REGISTRY NUMBER :: 474-74-8

LAST UPDATED :: 199509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C26-H43-N-O4

MOLECULAR WEIGHT :: 433.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,1911,1994

甘氨石胆酸安全信息

[ 危害码 (欧洲) ]:
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