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茶黄素

茶黄素用途

Theaflavin 是一种天然的甲型流感 (H1N1) 神经氨酸酶抑制剂。

茶黄素名称

[ CAS 号 ]:
4670-05-7

[ 中文名 ]:
茶黄素

[ 英文名 ]:
Theaflavin

[英文别名 ]:

Theaflavine
Theaflavin

茶黄素生物活性

[ 描述 ]:

Theaflavin 是一种天然的甲型流感 (H1N1) 神经氨酸酶抑制剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

天然产物 >> 黄酮类化合物

研究领域 >> 感染

[ 靶点 ]

Influenza A (H1N1) virus[1]

[体外研究]

在绿茶中发现的茶黄素被观察到抑制由最低对接能量强烈支持的H1N1 NA蛋白。茶黄素是传统上用于治疗流感感染的植物产品。绿茶特别富含多种酚类化合物,如茶黄素。茶黄素衍生物显示出显着的抗病毒活性。发现茶黄素通过形成氢键与NA的Arg118,Asp151,Asp 152,Arg193,Asp199,Asn344和Arg430等氨基酸残基相互作用[1]。

[参考文献]

[1]. Sahoo M, et al. Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking. Genomics Inform. 2016 Sep;14(3):96-103.

[相关活性小分子]

茶黄素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
926.2±65.0 °C at 760 mmHg

[ 熔点 ]:
240 °C

[ 分子式 ]:
C₂₉H₂₄O₁₂

[ 分子量 ]:
564.49

[ 闪点 ]:
314.3±27.8 °C

[ PSA ]:
156.91000

[ LogP ]:
1.61

[ 外观性状 ]:
固体;Red to Dark red to Brown powder to crystal

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.760

[ 储存条件 ]:
-20°C;存放于惰性气体之中;避免光,湿气 (分解),加热

茶黄素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE8382900

CHEMICAL NAME :: 5H-Benzocyclohepten-5-one, 1,8-bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-3,4 ,6-trihydroxy-

CAS REGISTRY NUMBER :: 4670-05-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H24-O12

MOLECULAR WEIGHT :: 564.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 42,75,1981

茶黄素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
3203001990

茶黄素合成路线

详细合成路线

茶黄素上下游产品

茶黄素上游产品

茶黄素下游产品

茶黄素海关

[ 海关编码 ]: 3203001990

茶黄素文献

Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1.

Food Chem. 138(4) , 2140-5, (2013)

In the small intestine, peptide transporter 1 (PEPT1) plays a role in the transport of di- and tripeptides. In this study, we investigated whether theaflavins (TFs) affect the absorption of small pept...

Polyphenols extracted from black tea (Camellia sinensis) residue by hot-compressed water and their inhibitory effect on pancreatic lipase in vitro.

J. Food Sci. 77(12) , H254-61, (2012)

Polyphenols, retained in black tea wastes following the commercial production of tea beverages, represent an underutilized resource. The purpose of this study was to investigate the potential use of h...

Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease.

Neurotox. Res. 23(2) , 166-73, (2013)

Neuroinflammation and apoptosis in the dopaminergic neurons of substantia nigra play an important role in the pathogenesis of experimental and clinical Parkinson's disease (PD). This study focused on ...

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茶黄素