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蟾毒灵

蟾毒灵用途

蟾毒灵(Bufalin)是重要蟾酥中的免疫活性成分,被报道体外水平对多种癌细胞有抑制作用。

蟾毒灵名称

[ CAS 号 ]:
465-21-4

[ 中文名 ]:
蟾毒灵

[ 英文名 ]:
Bufalin

[中文别名 ]:

[英文别名 ]:

3,14-dihydroxybufa-20,22-dienolide
(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-
5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-
3β,14β-dihydroxy-5β-bufa-20,22-dienolide
(3b,5b)-3,14-Dihydroxybufa-20,22-dienolide
Bufalin
MFCD00056525

蟾毒灵生物活性

[ 描述 ]:

蟾毒灵(Bufalin)是重要蟾酥中的免疫活性成分,被报道体外水平对多种癌细胞有抑制作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 类固醇

[参考文献]

[1]. Jiang L, et al. Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells. Tumour Biol. 2014 Nov;35(11):10931-41.

[2]. Wu SH, et al. Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways. Am J Chin Med. 2014;42(3):729-42.

[3]. Rong X, et al. Bufalin, a bioactive component of the chinese medicine chansu, inhibits inflammation and invasion of human rheumatoid arthritis fibroblast-like synoviocytes. Inflammation. 2014 Aug;37(4):1050-8.

[4]. Yan S, et al. Bufalin enhances TRAIL-induced apoptosis by redistributing death receptors in lipid rafts in breast cancer cells. Anticancer Drugs. 2014 Jul;25(6):683-9.

[5]. Wen L, et al. Anti-inflammatory and antinociceptive activities of bufalin in rodents. Mediators Inflamm. 2014;2014:171839.

[相关活性小分子]

蟾毒灵物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
556.6±50.0 °C at 760 mmHg

[ 熔点 ]:
242 - 243ºC

[ 分子式 ]:
C₂₄H₃₄O₄

[ 分子量 ]:
386.524

[ 闪点 ]:
189.0±23.6 °C

[ 精确质量 ]:
386.245697

[ PSA ]:
70.67000

[ LogP ]:
3.42

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.594

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

蟾毒灵MSDS

详细MSDS(安全技术说明书)

蟾毒灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2962500

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,14-dihydroxy-

CAS REGISTRY NUMBER :: 465-21-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C24-H34-O4

MOLECULAR WEIGHT :: 386.58

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 IQ OQ F- ET6OVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 740 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 140 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,189,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 137 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 24,222,1949

蟾毒灵安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 3462

[ WGK德国 ]:
3

[ RTECS号 ]:
EI2962500

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

蟾毒灵文献

Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.

Am. J. Chin. Med. 42(3) , 729-42, (2014)

Bufalin is a key component of a Chinese medicine (Chan Su) and has been proved effective in killing various cancer cells. Its role in inducing DNA damage and the inhibition of the DNA damage response ...

Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.

Sci. Rep. 5 , 17047, (2015)

Sodium taurocholate cotransporting polypeptide (NTCP) has been reported as a functional receptor for hepatitis B virus (HBV) infection. However, HBV could not efficiently infect HepG2 cells expressing...

Reversal effect of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line.

J. Tradit. Chin. Med. 34(6) , 678-83, (2014)

To probe insights into the reversal effect of bufalin on vincristine-acquired multidrug resistance (MDR) in human leukemia cell line K562/VCR.Proliferative inhibition rate and the reversal index (RI) ...

更多文献

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蟾毒灵