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华蟾毒它灵

华蟾毒它灵用途

华蟾毒它灵(Cinobufotalin)是由蟾蜍毒液分离出的蟾蜍甾烯,被报道有抗癌活性。

华蟾毒它灵作用

1、抗肿瘤作用
2、免役促进作用
3、抗病毒作用

华蟾毒它灵名称

[ CAS 号 ]:
1108-68-5

[ 中文名 ]:
华蟾素

[ 英文名 ]:
Cinobufotalin

[中文别名 ]:

[英文别名 ]:

MFCD00055946
5beta-Hydroxycinobufagin
cinobufotalin venom toad
Cinobufotlin
Cinobufotalin
CINOBUFOTALIN(RG)
cinobufatolin

华蟾毒它灵生物活性

[ 描述 ]:

华蟾毒它灵(Cinobufotalin)是由蟾蜍毒液分离出的蟾蜍甾烯,被报道有抗癌活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 癌症

[参考文献]

[1]. Kai S, et al. Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent. Biochem Biophys Res Commun. 2014 Sep 26;452(3):768-74.

[2]. Cheng L, et al. Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells. Tumour Biol. 2015 Feb 28.

[3]. Emam H, et al. Apoptotic cell death by the novel natural compound, cinobufotalin. Chem Biol Interact. 2012 Sep 30;199(3):154-60.

[相关活性小分子]

华蟾毒它灵物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
627.3±55.0 °C at 760 mmHg

[ 熔点 ]:
259 - 262ºC

[ 分子式 ]:
C₂₆H₃₄O₇

[ 分子量 ]:
458.544

[ 闪点 ]:
210.7±25.0 °C

[ 精确质量 ]:
458.230438

[ PSA ]:
109.50000

[ LogP ]:
0.79

[ 蒸汽压 ]:
0.0±4.2 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
2-8°C

华蟾毒它灵MSDS

华蟾毒它灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2991000

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-, 16-acetate

CAS REGISTRY NUMBER :: 1108-68-5

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C26-H34-O

MOLECULAR WEIGHT :: 362.60

WISWESSER LINE NOTATION :: T E6 B6653 1A R AX RO QHTTTT&J EQ GQ J1 N1 POV1 O- ET6O BHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5150 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,189,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 199 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 24,222,1949

华蟾毒它灵安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
EI2991000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

华蟾毒它灵合成路线

华蟾毒它灵上下游产品

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华蟾毒它灵文献

Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent.

Biochem. Biophys. Res. Commun. 452(3) , 768-74, (2014)

Lung cancer is a major cause of cancer-related mortality in the United States and around the world. Due to the pre-existing or acquired chemo-resistance, the current standard chemotherapy regimens onl...

Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells.

Tumour Biol. 36 , 5763-71, (2015)

Hepatocellular carcinoma (HCC) is a highly aggressive and lethal neoplasm with poor prognosis. The aim of this study is to investigate the anticancer activity of cinobufotalin, a bufadienolide isolate...

Comparative Analysis of the Bufonis Venenum by Using TLC, HPLC, and LC-MS for Different Extraction Methods.

J Pharmacopuncture 15 , 52-65, (2015)

Toad venom, called Chan-Su, is a traditional Oriental medicine secreted from the auricular and the skin glands of the Bufo bufo gargarizanz Cantor or B. melanosticus Schneider and has been widely used...

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