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日蟾蜍他灵

日蟾蜍他灵用途

Gamabufotalin (Gamabufagin)，蟾酥中主要的蟾蜍甾烯，由于其稳定性和低毒性被广泛用于抗癌治疗。

日蟾蜍他灵名称

[ CAS 号 ]:
465-11-2

[ 中文名 ]:
日本蟾蜍毒苷元

[ 英文名 ]:
Gamabufotalin

[中文别名 ]:

[英文别名 ]:

(3β,5β,11α)-3,11,14-Trihydroxybufa-20,22-dienolide
Gammabufotalin
3b,11a,14-Trihydroxy-5b-bufa-20,22-dienolide
Gamabufotalin
(3b,5b,11a)-3,11,14-Trihydroxybufa-20,22-dienolide
Gamabufagin
Gamabufogenin

日蟾蜍他灵生物活性

[ 描述 ]:

Gamabufotalin (Gamabufagin),蟾酥中主要的蟾蜍甾烯,由于其稳定性和低毒性被广泛用于抗癌治疗。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 类固醇

[参考文献]

[1]. Yu Z, et al. Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells. Mol Cancer. 2014 Aug 31;13:203.

[2]. Dong Y, et al. Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway. Apoptosis. 2011 Apr;16(4):394-403.

[相关活性小分子]

日蟾蜍他灵物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
595.8±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₄H₃₄O₅

[ 分子量 ]:
402.524

[ 闪点 ]:
203.4±23.6 °C

[ 精确质量 ]:
402.240631

[ PSA ]:
90.90000

[ LogP ]:
1.99

[ 蒸汽压 ]:
0.0±3.8 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
-20°C

日蟾蜍他灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2996800

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,11-alpha,14-trihydroxy-

CAS REGISTRY NUMBER :: 465-11-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H34-O5

MOLECULAR WEIGHT :: 402.58

WISWESSER LINE NOTATION :: L E5 B666TJ A1 CQ E1 IQ OQ F- ET6OVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,191,1963