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远华蟾蜍精

远华蟾蜍精用途

远华蟾蜍精(Telocinobufagin)是蟾酥分离提取的一种组份。

远华蟾蜍精名称

[ CAS 号 ]:
472-26-4

[ 中文名 ]:
蟾蜍精

[ 英文名 ]:
Telocinobufagin

[英文别名 ]:

3,5,14-Trihydroxybufa-20,22-dienolide
Telobufotoxin
5β-Bufa-20,22-dienolide, 3β,5,14-trihydroxy-
Telecinobufagin
Telocinobufogenin
(3β,5β)-3,5,14-Trihydroxybufa-20,22-dienolide
Bufa-20,22-dienolide, 3,5,14-trihydroxy-, (3β,5β)-
Telocinobufagin

远华蟾蜍精生物活性

[ 描述 ]:

远华蟾蜍精(Telocinobufagin)是蟾酥分离提取的一种组份。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

天然产物 >> 类固醇

[相关活性小分子]

远华蟾蜍精物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
589.6±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₄H₃₄O₅

[ 分子量 ]:
402.524

[ 闪点 ]:
201.0±23.6 °C

[ 精确质量 ]:
402.240631

[ PSA ]:
90.90000

[ LogP ]:
1.78

[ 蒸汽压 ]:
0.0±3.8 mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
-20°C

远华蟾蜍精毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2996700

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,5,14-trihydroxy-

CAS REGISTRY NUMBER :: 472-26-4

BEILSTEIN REFERENCE NO. :: 0056287

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H34-O5

MOLECULAR WEIGHT :: 402.58

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 IQ MQ OQ F- ET6OVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4340 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1102 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

远华蟾蜍精

远华蟾蜍精用途

远华蟾蜍精名称

远华蟾蜍精生物活性

远华蟾蜍精物理化学性质

远华蟾蜍精毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

远华蟾蜍精合成路线

详细合成路线

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