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积雪草酸

积雪草酸用途

Asiatic acid,是在 Centella asiatica 中发现的一种五环三萜,可诱导黑色素瘤细胞的凋亡,可用于治疗皮肤癌。Asiatic acid 还拥有抗炎活性。

积雪草酸名称

[ CAS 号 ]:
464-92-6

[ 中文名 ]:
亚细亚酸

[ 英文名 ]:
Asiatic acid

[中文别名 ]:

积雪草酸

[英文别名 ]:

2,3,23-TRIHYDROXY-12-URSEN-28-OIC ACID
(2α,3β)-2,3,23-Trihydroxyurs-12-en-28-oic acid
Asiatic acid
Asiantic acid
Asiaticacid
UNII-9PA5A687X5
MFCD00238541
Dammarolic acid
EINECS 482-720-9

积雪草酸生物活性

[ 描述 ]:

Asiatic acid,是在 Centella asiatica 中发现的一种五环三萜,可诱导黑色素瘤细胞的凋亡,可用于治疗皮肤癌。Asiatic acid 还拥有抗炎活性。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[参考文献]

[1]. Park BC, et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005 Jan 31;218(1):81-90.

[2]. Huang SS, et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857.

积雪草酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
609.4±55.0 °C at 760 mmHg

[ 熔点 ]:
325-330 °C(lit.)

[ 分子式 ]:
C₃₀H₄₈O₅

[ 分子量 ]:
488.699

[ 闪点 ]:
336.4±28.0 °C

[ 精确质量 ]:
488.350189

[ PSA ]:
97.99000

[ LogP ]:
6.46

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±4.0 mmHg at 25°C

[ 折射率 ]:
1.579

[ 储存条件 ]:
2-8°C

积雪草酸MSDS

积雪草酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918199090

积雪草酸合成路线

积雪草酸上下游产品

积雪草酸上游产品

积雪草酸下游产品

积雪草酸海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

积雪草酸文献

Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC-MS method.

J. Ethnopharmacol. 163 , 31-8, (2015)

Asiatic acid is one of the main components in the herb Centella asiatica, which is a well-known herbal medicine for its excellent pharmacological effects. To enhance the development potentials of asia...

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.

Int. Immunopharmacol. 24(2) , 232-8, (2015)

In the present study, the effect of asiatic acid, a natural triterpenoid compound, on murine experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism were examined in vi...

Effecting skin renewal: a multifaceted approach.

J. Cosmet. Dermatol. 10(2) , 126-30, (2011)

The skin undergoes intrinsic aging as a normal course, but exposure to ultraviolet (UV) light results in major cumulative damage that manifests as the typical aged photodamaged skin. UV irradiation pr...

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