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噻莫西酸

噻莫西酸用途

Timonacic 被用作治疗急性病和肝脏疾病的佐剂。通过诱导逆转,它也被用于治疗一些癌症病例。

噻莫西酸名称

[ CAS 号 ]:
444-27-9

[ 中文名 ]:
噻莫西酸

[ 英文名 ]:
Timonacic

[中文别名 ]:

[英文别名 ]:

(4R)-1,3-Thiazolidine-4-carboxylic acid
L-4-Thiazolidinecarboxylic acid
L-Thioproline
(R)-(-)-4-Thiazolidinecarboxylic acid
L- thiazolidine-4-carboxylic acid
MFCD00128958
EINECS 207-146-6
(4R)-4-Thiazolidinecarboxylic acid
(R)-Thiazolidine-4-carboxylic acid
4-thiazolidinecarboxylic acid

噻莫西酸生物活性

[ 描述 ]:

Timonacic 被用作治疗急性病和肝脏疾病的佐剂。通过诱导逆转,它也被用于治疗一些癌症病例。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

研究领域 >> 心血管疾病

[参考文献]

[1]. Bakry RS, et al. Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications. J Pharm Biomed Anal. 1998 May;17(1):95-101.

[相关活性小分子]

噻莫西酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
350.3±37.0 °C at 760 mmHg

[ 熔点 ]:
199 - 201ºC

[ 分子式 ]:
C₄H₇NO₂S

[ 分子量 ]:
133.169

[ 闪点 ]:
165.7±26.5 °C

[ 精确质量 ]:
133.019745

[ PSA ]:
74.63000

[ LogP ]:
-0.39

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
2-8℃

噻莫西酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ5425000

CHEMICAL NAME :: 4-Thiazolidinecarboxylic acid

CAS REGISTRY NUMBER :: 444-27-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H7-N-O2-S

MOLECULAR WEIGHT :: 133.18

WISWESSER LINE NOTATION :: T5M CSTJ EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Kidney, Ureter, Bladder - renal function tests depressed

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,778,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 875 mg/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 494 mg/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GMITAB Gazzetta Medica Italiana. (Turin, Italy) V.95-142, 1936-83. Volume(issue)/page/year: 131,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,68,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 715 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,837,1980 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Endocrine - effect on menstrual cycle

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,453,1987

噻莫西酸安全信息

[ 危险品运输编码 ]:
UN 2811

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2934999090

噻莫西酸合成路线

详细合成路线

噻莫西酸上下游产品

噻莫西酸上游产品

噻莫西酸下游产品

噻莫西酸海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%