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阿利马嗪酒石酸盐

阿利马嗪酒石酸盐用途

Alimemazine hemitartrate 是通常用作止痒剂的吩噻嗪衍生物,也是血凝素 (HA)-受体的拮抗剂。

阿利马嗪酒石酸盐名称

[ CAS 号 ]:
4330-99-8

[ 中文名 ]:
酒石酸异丁嗪

[ 英文名 ]:
Alimemazine hemitartrate

[中文别名 ]:

[英文别名 ]:

Trimeprazine Tartrate
Alimemazine
EINECS 224-368-9
MFCD00242594

阿利马嗪酒石酸盐生物活性

[ 描述 ]:

Alimemazine hemitartrate 是通常用作止痒剂的吩噻嗪衍生物,也是血凝素 (HA)-受体的拮抗剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

研究领域 >> 炎症/免疫

[ 靶点 ]

HA receptor[1]

[参考文献]

[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

[相关活性小分子]

阿利马嗪酒石酸盐物理化学性质

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₁₈H₂₂N₂S_.1/₂C₄H₆O₆

[ 分子量 ]:
373.49

[ PSA ]:
178.62000

[ LogP ]:
6.98140

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
Refrigerator

阿利马嗪酒石酸盐MSDS

详细MSDS(安全技术说明书)

阿利马嗪酒石酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO6475000

CAS REGISTRY NUMBER :: 4330-99-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C36-H44-N4-S2.C4-H6-O6

MOLECULAR WEIGHT :: 747.06

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&1N1&1 &OVYQYQVO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,41,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5558 No. of Facilities: 137 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1472 (estimated) No. of Female Employees: 835 (estimated)

阿利马嗪酒石酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
Missing Phrase - N15.00950417

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
3249

[ RTECS号 ]:
SO6475000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2934300000

阿利马嗪酒石酸盐海关

[ 海关编码 ]: 2934300000

[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

阿利马嗪酒石酸盐文献

Alterations in intracranial pressure following ketamine anesthesia in hydrocephalic children.

Indian J. Pediatr. 51(408) , 25-8, (1984)

Pruritus in burns. Comments from the Vancouver General Hospital Burn Unit, Vancouver, British Columbia.

J. Burn Care Rehabil. 9(3) , 310-1, (1988)

Behavioural changes in children following minor surgery--is premedication beneficial?

Acta Anaesthesiol. Belg. 43(3) , 173-9, (1992)

One hundred and twenty-three male children, aged one to ten years, were studied to determine the influence of premedication on changes in patterns of behaviour following hospitalization for repair of ...

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