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芬苯达唑

芬苯达唑用途

Fenbendazole是广谱的苯并咪唑类驱虫剂,对胃肠寄生虫有效。

芬苯达唑名称

[ CAS 号 ]:
43210-67-9

[ 中文名 ]:
芬苯达唑

[ 英文名 ]:
fenbendazole

[中文别名 ]:

[英文别名 ]:

Fenbendazole
HOE-881V
SAFEGARD
MFCD00144301
hoe881
fenbendazol
EINECS 256-145-7
Febendazole
Fenbedazole
PANACUR

芬苯达唑生物活性

[ 描述 ]:

Fenbendazole是广谱的苯并咪唑类驱虫剂,对胃肠寄生虫有效。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. http://en.wikipedia.org/wiki/Fenbendazole

[相关活性小分子]

芬苯达唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
541.4±42.0 °C at 760 mmHg

[ 熔点 ]:
233°C

[ 分子式 ]:
C₁₅H₁₃N₃O₂S

[ 分子量 ]:
299.348

[ 闪点 ]:
281.2±27.9 °C

[ 精确质量 ]:
299.072845

[ PSA ]:
92.31000

[ LogP ]:
4.34

[ 外观性状 ]:
白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.679

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
水溶性：不溶

芬苯达唑MSDS

芬苯达唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6520500

CHEMICAL NAME :: 2-Benzimidazolecarbamic acid, 5-(phenylthio)-, methyl ester

CAS REGISTRY NUMBER :: 43210-67-9

LAST UPDATED :: 199606

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C15-H13-N3-O2-S

MOLECULAR WEIGHT :: 299.37

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GSR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 gm/kg/14D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 2 mg/L

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

芬苯达唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DD6520500

[ 海关编码 ]:
2933990090

芬苯达唑合成路线

芬苯达唑上下游产品

芬苯达唑上游产品

芬苯达唑下游产品

芬苯达唑制备

【方法一】
由5-氯-2-硝基苯胺与苯硫醇反应，制得5-苯硫基-2-硝基苯胺，收率91%。经硫酸亚铁-铁粉还原得3-苯硫基邻苯二胺，收率90%。最后与S-甲基-氰胺基甲酸甲酯环合得到苯硫苯咪唑。

芬苯达唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

芬苯达唑文献

Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

Epidemiology. Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales.

Science 347(6218) , 175-7, (2015)

Parasitic worms modulate host immune responses in ways that affect microbial co-infections. For this reason, anthelmintic therapy may be a potent tool for indirectly controlling microbial pathogens. H...

Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications.

Vet. J. 181(3) , 241-50, (2009)

Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to alben...

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