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1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺用途

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid),与阳离子磷脂结合,提高裸 siRNA 的转染效率。

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺名称

[ CAS 号 ]:
4004-05-1

[ 中文名 ]:
二油酰基 L-α-磷脂酰乙醇胺

[ 英文名 ]:
DOPE

[中文别名 ]:

[英文别名 ]:

DOPE
Dioleoyl phosphoethanolamine
L-A-phosphatidylethanolamine dioleoyl
1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine
1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine
3-SN-PHOSPHATIDYLETHANOLAMINE,1,2-DIDEOYL
MFCD00057986
1,2-dioleoyl-sn-glycero-3-phosphoethanoloamine
COATSOME ME-8181 (DOPE)
DIOLEOYL PHOSPHATIDYL ETHANOLAMINE

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺生物活性

[ 描述 ]:

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid),与阳离子磷脂结合,提高裸 siRNA 的转染效率。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[ 靶点 ]

IC50: helper lipid for liposome[1]

[体外研究]

在本研究中,每个siRNA被封装在LNP中(阳离子脂质-A:PEG2000-DMPE:DOPE=47.8:5.18:47.1摩尔百分比)[1]。由于LNP为中性脂质体,LNP对巨噬细胞和DCs具有敲除(KD)效应,含LNP的脂质体具有融合性[1]。LNP/siRNA显著抑制巨噬细胞和树突状细胞CD45蛋白的表达,抑制率为30%,但不抑制单核细胞、中性粒细胞、浆细胞样树突状细胞或B细胞[1]。LNP不仅对小鼠,而且对人巨噬细胞和树突状细胞都有可能成为一种有效的siRNA传递系统[1]。

[参考文献]

[1]. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol. 2019 Mar;24(3):263-268.

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺物理化学性质

[ 密度 ]:
1.008g/cm3

[ 沸点 ]:
759.2±70.0 °C at 760 mmHg

[ 熔点 ]:
200 °C

[ 分子式 ]:
C₄₁H₇₈NO₈P

[ 分子量 ]:
744.034

[ 闪点 ]:
413.0±35.7 °C

[ 精确质量 ]:
743.546509

[ PSA ]:
144.19000

[ LogP ]:
14.79

[ 外观性状 ]:
冻干的粉末

[ 蒸汽压 ]:
0.0±5.5 mmHg at 25°C

[ 折射率 ]:
1.484

[ 储存条件 ]:
-20°C;存放于惰性气体之中;避免空气,加热

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺MSDS

详细MSDS(安全技术说明书)

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H319-H331-H336-H351-H361d-H372

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22;R38;R40;R48/20/22

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
UN 1888

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2931900090

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺合成路线

详细合成路线

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺上下游产品

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺上游产品

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺下游产品

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺文献

Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.

J. Virol. 89(10) , 5714-23, (2015)

Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (Rd...

Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.

Biol. Chem. 395(7-8) , 801-12, (2014)

As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factor...

Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections.

Pharm. Res. 32(5) , 1546-56, (2015)

To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides.Cellular uptake of three AMPs (PK-12-KKP, SA-3 and TPk) and a cell-penetrating peptide ...

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