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茜素络合指示剂

茜素络合指示剂用途

【用途一】
配成0.5%的水溶液，作络合滴定指示剂
【用途二】
分光测定氟，用作络合指示剂；测定铝、钡、锰、镍、钙、镉、钴、铜、铟、铅、锶、锌和稀土。配成0.5%的水溶液，做络合滴定指示剂。

茜素络合指示剂名称

[ CAS 号 ]:
3952-78-1

[ 中文名 ]:
茜素络合指示剂

[ 英文名 ]:
alizarin complexone

[中文别名 ]:

[英文别名 ]:

Alizarin-3-methylimino-N,N-diacetic Acid
Alizarin-3-methyliminodiacetic acid
EINECS 223-544-2
MFCD00001202
Alizarin complexone
Alizarin Fluorine Blue

茜素络合指示剂生物活性

[ 描述 ]:

茜素络合剂是一种钙示踪剂和螯合剂。茜素络合剂是ROS相关病毒2逆转录酶(RAV-2 RT)抑制剂[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 逆转录酶

[参考文献]

[1]. Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15(3):205-216.

[2]. Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper(II)-chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79.

茜素络合指示剂物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
687.1±55.0 °C at 760 mmHg

[ 熔点 ]:
~185 °C (dec.)

[ 分子式 ]:
C₁₉H₁₅NO₈

[ 分子量 ]:
385.324

[ 闪点 ]:
369.4±31.5 °C

[ 精确质量 ]:
385.079773

[ PSA ]:
152.44000

[ LogP ]:
3.38

[ 外观性状 ]:
红色至棕色粉末

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.720

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 稳定性 ]:
Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
Slightly soluble (0.2 g/L)

茜素络合指示剂MSDS

茜素络合指示剂毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH0585000

CHEMICAL NAME :: Acetic acid, (((3,4-dihydroxy-2-anthraquinonyl)methyl)imino)di-

CAS REGISTRY NUMBER :: 3952-78-1

BEILSTEIN REFERENCE NO. :: 2190028

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H15-N-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,180,1972

茜素络合指示剂安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AH0585000

[ 海关编码 ]:
2922509090

茜素络合指示剂合成路线

茜素络合指示剂上下游产品

茜素络合指示剂上游产品

茜素络合指示剂下游产品

茜素络合指示剂制备

【方法一】
由茜素和亚氨基二乙酸反应：16g茜素和22.5g亚氨基二乙酸悬浮于30ml水中，用含13.5g氢氧化钠的60ml水溶液处理。边搅拌滴加37%甲醛10ml。混合物用水稀释至230ml。加热至75℃，边搅拌边滴加37%甲醛7ml，保温14g。稀释至750ml，在45℃用5N盐酸处理至无沉淀出现为止。滤出结晶为粗品。将粗品溶于蒸馏水，加氢氧化钠溶液溶解，再加盐酸使之重新析出沉淀，过滤，洗涤可得纯品。未反应的茜素可用乙醚提取的方法除去。

茜素络合指示剂海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

茜素络合指示剂文献

[Histochemical staining methods for lanthanum].

Rinsho Byori. 59(9) , 844-51, (2011)

In recent years lanthanum compounds have been widely used in the optical and electronic industries. Although release of lanthanum (La) into the environment and exposure to humans are feared, acute or ...

Isometric Scaling in Developing Long Bones Is Achieved by an Optimal Epiphyseal Growth Balance.

PLoS Biol. 13 , e1002212, (2015)

One of the major challenges that developing organs face is scaling, that is, the adjustment of physical proportions during the massive increase in size. Although organ scaling is fundamental for devel...

Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models.

J. Bone Miner Res. 29(12) , 2688-96, (2014)

It has been suggested that metastasis-initiating cells gain a foothold in bone by homing to a metastastatic microenvironment (or "niche"). Whereas the precise nature of this niche remains to be establ...

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