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碘乙酸 N-羟基琥珀酰亚胺酯

碘乙酸 N-羟基琥珀酰亚胺酯用途

SIA Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

碘乙酸 N-羟基琥珀酰亚胺酯名称

[ CAS 号 ]:
39028-27-8

[ 中文名 ]:
碘乙酸 N-羟基琥珀酰亚胺酯

[ 英文名 ]:
SIA Crosslinker

[中文别名 ]:

[英文别名 ]:

1-(2-Iodoacetoxy)-2,5-pyrrolidinedione
N-SucciniMidyl Iodoacetate
2,5-Pyrrolidinedione, 1-[(2-iodoacetyl)oxy]-
N-(Iodoacetoxy)succinimide
1-(2-Iodoacetoxy)pyrrolidine-2,5-dione
Iodoacetic Acid N-Succinimidyl Ester
(2,5-dioxopyrrolidin-1-yl) 2-iodoacetate
N-Succinimidyl iodoacetate(SIA)

碘乙酸 N-羟基琥珀酰亚胺酯生物活性

[ 描述 ]:

SIA Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

[ 靶点 ]

Non-cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接体连接ADC细胞毒素[1]。

[参考文献]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

碘乙酸 N-羟基琥珀酰亚胺酯物理化学性质

[ 密度 ]:
2.1±0.1 g/cm3

[ 沸点 ]:
315.6±44.0 °C at 760 mmHg

[ 熔点 ]:
148ºC

[ 分子式 ]:
C₆H₆INO₄

[ 分子量 ]:
283.021

[ 闪点 ]:
144.7±28.4 °C

[ 精确质量 ]:
282.934143

[ PSA ]:
63.68000

[ LogP ]:
-0.76

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
DMF: 50 mg/mL

碘乙酸 N-羟基琥珀酰亚胺酯MSDS

碘乙酸 N-羟基琥珀酰亚胺酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

碘乙酸 N-羟基琥珀酰亚胺酯合成路线

碘乙酸 N-羟基琥珀酰亚胺酯上下游产品

碘乙酸 N-羟基琥珀酰亚胺酯上游产品

碘乙酸 N-羟基琥珀酰亚胺酯下游产品

碘乙酸 N-羟基琥珀酰亚胺酯海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

碘乙酸 N-羟基琥珀酰亚胺酯文献

A method for the preparation of protein-protein conjugates of predetermined composition.

J. Immunol. Methods 24 , 321-336, (1978)

A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reacti...

Conjugation to preactivated proteins using divinylsulfone and iodoacetic acid.

J. Immunol. Methods 181 , 187-200, (1995)

Two methods for the preactivation of proteins and conjugation of peptides to proteins under mild conditions are presented. Preactivation of proteins with divinylsulfone (DVS) permits peptide conjugati...

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.

ACS Nano 7 , 9001-9, (2013)

Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with nu...

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