溴乙酸-N-琥珀酰亚胺酯

溴乙酸-N-琥珀酰亚胺酯用途

SBA crosslinker, or N-Succinimidyl bromoacetate, is a sulfhydryl (thiol) and amino reactive heterobifunctional protein crosslinking reagent. SBA protein crosslinker is non-cleavable and is among the shortest amine and sulfhydryl reactive crosslinking reagents known with a spacer arm length of only 1.5 Angstroms. SBA Crosslinker is useful for making antibody drug conjugates (ADCs).

溴乙酸-N-琥珀酰亚胺酯名称

[ CAS 号 ]:
42014-51-7

[ 中文名 ]:
溴乙酸 N-羟基琥珀酰亚胺酯

[ 英文名 ]:
1-(2-Bromoacetoxy)-2,5-pyrrolidinedione

[中文别名 ]:

[英文别名 ]:

N-SucciniMidyl BroMoacetate
2,5-Dioxopyrrolidin-1-yl 2-bromoacetate
(2,5-dioxopyrrolidin-1-yl) 2-bromoacetate
Bromoacetic acid N-hydroxysuccinimide ester
2,5-Pyrrolidinedione, 1-((bromoacetyl)oxy)-
MFCD00058571
1-(2-Bromoacetoxy)pyrrolidine-2,5-dione
Bromoacetic Acid N-Succinimidyl Ester
1-(2-Bromoacetoxy)-2,5-pyrrolidinedione
N-(Bromoacetoxy)succinimide

溴乙酸-N-琥珀酰亚胺酯物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
291.7±42.0 °C at 760 mmHg

[ 熔点 ]:
115-116ºC

[ 分子式 ]:
C₆H₆BrNO₄

[ 分子量 ]:
236.020

[ 闪点 ]:
130.2±27.9 °C

[ 精确质量 ]:
234.948013

[ PSA ]:
63.68000

[ LogP ]:
-1.11

[ 外观性状 ]:
powder

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
acetone: 25 mg/mL

溴乙酸-N-琥珀酰亚胺酯MSDS

详细MSDS(安全技术说明书)

溴乙酸-N-琥珀酰亚胺酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

溴乙酸-N-琥珀酰亚胺酯合成路线

详细合成路线

溴乙酸-N-琥珀酰亚胺酯上下游产品

溴乙酸-N-琥珀酰亚胺酯上游产品

溴乙酸-N-琥珀酰亚胺酯下游产品

溴乙酸-N-琥珀酰亚胺酯海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

溴乙酸-N-琥珀酰亚胺酯文献

Preparation of peptide-protein immunogens using N-succinimidyl bromoacetate as a heterobifunctional crosslinking reagent.

Anal. Biochem. 155 , 95-102, (1986)

Synthetic peptides derived from human fibrin were unidirectionally conjugated to three carrier proteins (bovine serum albumin, bovine alpha-lactalbumin, and keyhole limpet hemocyanin) by a method that...

Production of antibodies against degradative neoepitopes in aggrecan.

Methods Mol. Med. 100 , 237-50, (2004)

The use of synthetic peptides to generate rabbit polyclonal anticatabolic neoepitope antibodies that can be used to study the presence of defined proteolytic cleavage sites in aggrecan is described. P...

Conjugation of synthetic peptides to proteins: quantitation from S-carboxymethylcysteine released upon acid hydrolysis.

Anal. Biochem. 187(1) , 136-40, (1990)

A method described here for conjugating synthetic peptides to carrier proteins provides a convenient method for determining peptide-to-carrier protein ratios. N-Bromoacetyl-containing peptides are rea...

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