孕二烯二酮

孕二烯二酮用途

(-)-(E)-古古尔甾酮是Z-古尔甾酮的代谢产物。Guggulsterone是guggulipid的一种活性成分,guggulipid是一种阿育吠陀药物,来源于Commiphora mukul。Guggulsterone具有降血脂活性[1]。

孕二烯二酮名称

[ CAS 号 ]:
39025-24-6

[ 中文名 ]:
孕二烯二酮

[ 英文名 ]:
(E)-Guggulsterone

[中文别名 ]:

反式-固甾酮

[英文别名 ]:

Z-guggulsterone
UNII:9B259YE66O
E-guggulsterone
Pregna-4,17-diene-3,16-dione, (17E)-
trans-Guggulsterone
Guggulsterone
(17E)-Pregna-4,17-diene-3,16-dione
Pregna-4,17(20)-diene-3,16-dione, (17E)-
(17E)-Pregna-4,17(20)-diene-3,16-dione
GUGGULSTERONE E

孕二烯二酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. N. VERMA, et al. Pharmacokinetics of Guggulsterone after Intravenous and Oral Administration in Rats.

孕二烯二酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
463.3±45.0 °C at 760 mmHg

[ 熔点 ]:
170-171.5°

[ 分子式 ]:
C₂₁H₂₈O₂

[ 分子量 ]:
312.446

[ 闪点 ]:
172.3±25.7 °C

[ 精确质量 ]:
312.208923

[ PSA ]:
34.14000

[ LogP ]:
3.65

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.557

[ 储存条件 ]:
室温

孕二烯二酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H335

[ 警示性声明 ]:
P261

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
37-52/53

[ 安全声明 (欧洲) ]:
61-36

[ 危险品运输编码 ]:
NONH for all modes of transport

孕二烯二酮文献

Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.

Biochim. Biophys. Acta 1844(9) , 1684-93, (2014)

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative...

Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation.

Int. Immunopharmacol. 26 , 194-202, (2015)

Guggulsterone (GS), a plant steroid and a compound found at high levels in Commiphora myrrha, exhibits anti-inflammatory, anti-cancer, and cholesterol-lowering effects. However, the potential of GS to...

CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.

Mol. Pharmacol. 87(5) , 878-89, (2015)

Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression ...

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