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4-氧代-维A酸

4-氧代-维A酸用途

all-trans-4-Oxoretinoic acid,是维生素A 的活性代谢物,可通过作用核维甲酸受体 (RARs) 来诱导基因转录。

4-氧代-维A酸名称

[ CAS 号 ]:
38030-57-8

[ 中文名 ]:
4-氧代-维A酸

[ 英文名 ]:
all-trans-4-Oxoretinoic acid

[中文别名 ]:

[英文别名 ]:

4-keto-Retinoic Acid
4-oxo-all-rans-retinoic acid
4-Oxoretinoic Acid
all-trans-4-Oxoretinoic Acid
4-oxo-all-trans-retinoic acid
all-trans 4-Keto Retinoic Acid
4-oxo-Retinoic acid
4-Ketoretinoic Acid
4-Oxo-atRA
4-Oxotretinoin

4-氧代-维A酸生物活性

[ 描述 ]:

all-trans-4-Oxoretinoic acid,是维生素A 的活性代谢物,可通过作用核维甲酸受体 (RARs) 来诱导基因转录。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

全反式-4-氧代氨基酸,维生素A的活性代谢产物,通过与核视黄酸受体(RARs)的结合诱导基因转录[1]。全反式-4-氧代氨基酸是视黄酸(RA)的生物活性几何异构体[2]。

[参考文献]

[1]. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.

[2]. Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.

[相关活性小分子]

4-氧代-维A酸物理化学性质

[ 密度 ]:
1.07g/cm3

[ 沸点 ]:
509.9ºC at 760 mmHg

[ 熔点 ]:
175-178°C (分解)

[ 分子式 ]:
C₂₀H₂₆O₃

[ 分子量 ]:
314.41900

[ 闪点 ]:
276.3ºC

[ 精确质量 ]:
314.18800

[ PSA ]:
54.37000

[ LogP ]:
4.78160

[ 折射率 ]:
1.565

[ 储存条件 ]:
2-8℃

4-氧代-维A酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH6599800

CHEMICAL NAME :: Retinoic acid, 4-oxo-

CAS REGISTRY NUMBER :: 38030-57-8

LAST UPDATED :: 199007

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H26-O3

MOLECULAR WEIGHT :: 314.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,33A,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 100,162,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 39 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4900 ug/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988

4-氧代-维A酸

4-氧代-维A酸用途

4-氧代-维A酸名称

4-氧代-维A酸生物活性

4-氧代-维A酸物理化学性质

4-氧代-维A酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

4-氧代-维A酸合成路线

详细合成路线

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