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2-氯-N6-环戊基腺苷

2-氯-N6-环戊基腺苷用途

CCPA(2-氯-N6-环戊基糖苷)是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

2-氯-N6-环戊基腺苷名称

[ CAS 号 ]:
37739-05-2

[ 中文名 ]:
2-氯-N6-环戊基腺苷

[ 英文名 ]:
ccpa

[中文别名 ]:

2-氯-n-环戊基腺苷酸

[英文别名 ]:

2-Chloro-N-cyclopentyladenosine
2-Chloro-N6-cyclopentyladenosine

2-氯-N6-环戊基腺苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

2-氯-N6-环戊基腺苷物理化学性质

[ 密度 ]:
1.87g/cm3

[ 沸点 ]:
617.3ºC at 760mmHg

[ 分子式 ]:
C₁₅H₂₀ClN₅O₄

[ 分子量 ]:
369.80

[ 闪点 ]:
327.1ºC

[ 精确质量 ]:
369.12000

[ PSA ]:
125.55000

[ LogP ]:
0.51870

[ 外观性状 ]:
灰白色至淡黄色固体

[ 折射率 ]:
1.824

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 1.7 mg/mL, insoluble

2-氯-N6-环戊基腺苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7357555

CHEMICAL NAME :: Adenosine, 2-chloro-N-cyclopentyl-

CAS REGISTRY NUMBER :: 37739-05-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H20-Cl-N5-O4

MOLECULAR WEIGHT :: 369.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1305,1994

2-氯-N6-环戊基腺苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU7357555

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2-氯-N6-环戊基腺苷文献

Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse.

Eur. J. Neurosci. 42 , 1775-87, (2015)

Adenosine receptors (ARs) are present in the motor terminals at the mouse neuromuscular junction. ARs and the presynaptic muscarinic acetylcholine receptors (mAChRs) share the functional control of th...

Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT.

Clin. Microbiol. Infect. 20(11) , O960-8, (2014)

Chronic cavitary pulmonary aspergillosis (CCPA) is an uncommon but serious pulmonary disease of humans, with an annual mortality rate of 10-30%. It is caused by the fungus Aspergillus fumigatus. Patie...

Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281.

Cell. Signal. 27(5) , 1008-18, (2015)

Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemothera...

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