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叔辛酚氯

叔辛酚氯用途

Clofoctol是一种抗生素, 用于治疗革兰氏阳性菌引起的呼吸道, 耳, 鼻, 咽喉感染。仅对对革兰氏阳性菌起作用, 可渗透入人类肺组织。

叔辛酚氯名称

[ CAS 号 ]:
37693-01-9

[ 中文名 ]:
氯福克酚

[ 英文名 ]:
Clofoctol

[中文别名 ]:

叔辛酚氯

[英文别名 ]:

EINECS 253-632-6
Clofoctolum
Octofene
clofoctol

叔辛酚氯生物活性

[ 描述 ]:

Clofoctol是一种抗生素, 用于治疗革兰氏阳性菌引起的呼吸道, 耳, 鼻, 咽喉感染。仅对对革兰氏阳性菌起作用, 可渗透入人类肺组织。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

叔辛酚氯物理化学性质

[ 密度 ]:
1.127 g/cm3

[ 沸点 ]:
447.7ºC at 760 mmHg

[ 熔点 ]:
78°

[ 分子式 ]:
C₂₁H₂₆Cl₂O

[ 分子量 ]:
365.33700

[ 闪点 ]:
160.4ºC

[ 精确质量 ]:
364.13600

[ PSA ]:
20.23000

[ LogP ]:
7.00360

[ 折射率 ]:
1.555

[ 储存条件 ]:
2-8°C

叔辛酚氯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL0533000

CHEMICAL NAME :: Phenol, 2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethyl butyl)-

CAS REGISTRY NUMBER :: 37693-01-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H26-Cl2-O

MOLECULAR WEIGHT :: 365.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3830852

叔辛酚氯安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
SL0533000

叔辛酚氯文献

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Br. J. Pharmacol. 171(19) , 4478-89, (2014)

Finding new indications for existing drugs, also known as drug repositioning or repurposing, is a powerful approach to accelerate drug discovery and development. The unfolded protein response pathways...

A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay.

Drugs Exp. Clin. Res. 14(1) , 39-43, (1988)

A microbiological assay was undertaken to measure the amounts of clofoctol in human plasma and pulmonary tissue, and to investigate its pharmacokinetics. Clofoctol was extracted from samples using eth...

Alteration of membrane permeability in Bacillus subtilis by clofoctol.

J. Gen. Microbiol. 129(4) , 1089-95, (1983)

When Bacillus subtilis was treated with a bacteriostatic concentration of clofoctol [2-(2,4-dichlorobenzyl)-4-(tetramethyl-1,1,3,3-butyl)phenol], UV-absorbing material was released. Electron micrograp...

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