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仲丁威

仲丁威用途

Fenobucarb 是一种广泛使用的氨基甲酸酯杀虫剂。Fenobucarb 通过炎症、氧化应激、变性和凋亡等途径诱导斑马鱼发育神经毒性。Fenobucarb 可能对动物心脑血管系统有危害。

仲丁威名称

[ CAS 号 ]:
3766-81-2

[ 中文名 ]:
仲丁威

[ 英文名 ]:
Fenobucarb

[中文别名 ]:

[英文别名 ]:

(RS)-2-sec-butylphenyl methylcarbamate
Fenobucarb
Phenol, 2-(1-methylpropyl)-, methylcarbamate
Carvil
EINECS 223-188-8
Fenocarb
(2-butan-2-ylphenyl) N-methylcarbamate
2-sec-Butylphenyl methylcarbamate
Bassa
2-(1-methylpropyl)phenyl methylcarbamate

仲丁威生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Xiao-Yu Zhu, et al. Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish. Neurotoxicology. 2020 Jul;79:11-19.

[2]. Xiao-Yu Zhu, et al. Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish. Aquat Toxicol. 2019 Apr;209:34-41.

仲丁威物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
282.5±23.0 °C at 760 mmHg

[ 分子式 ]:
C₁₂H₁₇NO₂

[ 分子量 ]:
207.269

[ 闪点 ]:
124.7±22.6 °C

[ 精确质量 ]:
207.125931

[ PSA ]:
38.33000

[ LogP ]:
3.04

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.505

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

仲丁威MSDS

详细MSDS(安全技术说明书)

仲丁威毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FB5425000

CHEMICAL NAME :: Carbamic acid, methyl-, o-sec-butylphenyl ester

CAS REGISTRY NUMBER :: 3766-81-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C12-H17-N-O2

MOLECULAR WEIGHT :: 207.30

WISWESSER LINE NOTATION :: 4R BOVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 8,41,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,371,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 173 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,57,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955- Volume(issue)/page/year: 15,132,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,724,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,724,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 141 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 51,137,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-JAPAN:TWA 5 mg/m3;Skin JAN 1993

仲丁威安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;T: Toxic;F: Flammable;

[ 风险声明 (欧洲) ]:
R22;R50/53

[ 安全声明 (欧洲) ]:
S60-S61-S45-S24-S16-S7

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
FB5425000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2922499915

仲丁威上下游产品

仲丁威上游产品

仲丁威下游产品

仲丁威制备

1.在0℃以下将液态光气通入邻仲丁基酚的甲苯溶液中，然后逐渐加入氢氧化钠溶液，制得氯甲酸邻促丁其苯酯（甲苯溶液），在快速搅拌下，与氢氧化钠溶液同时滴入甲胺水溶液中，室温下反应15min，即生成仲丁威。原料消耗定额：邻仲丁基酚（97.5%）770kg/t、光气650kg/t、一甲胺（40%）390kg/t、烧碱（30%）220kg/t、甲苯100kg/t、盐酸（30%）10kg/t。

2.烃化苯酚、1-正丁烯在硫酸催化下反应，配比为1∶1.4（MOL），反应温度134～136℃；也可采用CaCl3为催化剂气相连续合成邻仲丁基苯酚。

3.酯化将甲苯冷却至0℃以下，通入适量光气，然后加入经蒸馏处理的邻仲丁基苯酚，并滴加氢氧化钠溶液，控制反应温度小于0℃，终点狆犎值6～7，得氯甲酸邻仲丁基苯酯。

4.氨解先将氯甲酸邻仲丁基苯酯冷却至－10℃，开始滴加一甲胺及氢氧化钠溶液，使温度＜0℃，终点狆犎值7～8，继续保温0.5h，使反应完全，经脱溶回收甲苯，即得产品仲丁威。

仲丁威海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

仲丁威文献

QSAR study on permeability of hydrophobic compounds with artificial membranes.

Bioorg. Med. Chem. 15 , 3756-67, (2007)

We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of...

The role of methanol addition to water samples in reducing analyte adsorption and matrix effects in liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1389 , 76-84, (2015)

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis coupled simply with water filtering before injection has proven to be a simple, economic and time-saving method for analyzing trace-l...

[Effects of rice cleaning and cooking process on the residues of flutolanil, fenobucarb, silafluofen and buprofezin in rice].

Shokuhin Eiseigaku Zasshi 44(1) , 7-12, (2003)

We studied the effect of cleaning and cooking on the residues of flutolanil, fenobucarb, silafluofen and buprofezin in rice. The rice had been sprayed in a paddy field in Wakayama city, with 3 kinds o...

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仲丁威