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盐酸氯己定

盐酸氯己定用途

皮肤消毒，冲洗伤口及手术器械的浸泡及消毒；用作表面活性型杀菌剂，具有相当强的广谱抑菌、杀菌作用，对革兰氏阳性菌及革兰氏阴性菌均有效。

盐酸氯己定名称

[ CAS 号 ]:
3697-42-5

[ 中文名 ]:
盐酸氯己定

[ 英文名 ]:
Chlorhexidine Dihydrochloride

[中文别名 ]:

[英文别名 ]:

Chlorhexidine HCl
1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane
Chlorhexidine Dihydrochloride
Chlorhexidine hydrochloride
1,1’-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
Chlorhexidine 2HCl
EINECS 200-636-0
UNII-E64XL9U38K
MFCD00068998
Chlorhexidine (dihydrochloride)

盐酸氯己定生物活性

[ 描述 ]:

Chlorhexidine二盐酸盐是一种抗菌剂, 用作防腐剂和其它用途。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

盐酸氯己定物理化学性质

[ 沸点 ]:
699.3ºC at 760mmHg

[ 熔点 ]:
255-262 ºC

[ 分子式 ]:
C₂₂H₃₂Cl₄N₁₀

[ 分子量 ]:
578.369

[ 闪点 ]:
376.7ºC

[ 精确质量 ]:
576.156555

[ PSA ]:
167.58000

[ LogP ]:
7.88780

[ 外观性状 ]:
白色至淡黄色粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
0.06 g/100 mL (20 ºC)

盐酸氯己定MSDS

详细MSDS(安全技术说明书)

盐酸氯己定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XA5285000

CHEMICAL NAME :: 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, dihydrochloride

CAS REGISTRY NUMBER :: 3697-42-5

LAST UPDATED :: 199303

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H30-Cl2-N10.2Cl-H

MOLECULAR WEIGHT :: 578.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

盐酸氯己定安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
53-45-61-36-26

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
MA4375000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

盐酸氯己定制备

由产生放线菌酮的放线菌发酵提取，也可由链霉素、制霉菌素等发酵液中的副产品制得。

盐酸氯己定文献

Evaluation of preventive programs in high caries active preschool children.

Swed. Dent. J. 37(1) , 23-9, (2013)

Although caries prevalence in preschool children has dramatically decreased during the last decades it is still a large problem for a minor group of these children. Great efforts have been invested in...

Effect of irrigation with Tetraclean on bacterial leakage of obturated root canals.

N. Y. State Dent. J. 80(3) , 39-43, (2014)

The purpose of the study presented here was to evaluate the effect of Tetraclean, Hypoclean, Chlor-XTRA, 2% chlorhexidine and 6% sodium hypochlorite/17% EDTA as a final irrigant on bacterial leakage o...

Short-term decline in all-cause acquired infections with the routine use of a decontamination regimen combining topical polymyxin, tobramycin, and amphotericin B with mupirocin and chlorhexidine in the ICU: a single-center experience.

Crit. Care Med. 42(5) , 1121-30, (2014)

In a multicenter, placebo-controlled, randomized, double-blind trial, we showed that acquired infections in intubated patients were reduced by the combination of topical polymyxin plus tobramycin and ...

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