牡荆素

牡荆素用途

Vitexin 是一种 c-糖基化的黄酮,存在于多种药用植物中,例如榕树(Ficus deltoid) 和螺旋藻 (Spirodela polyrhiza)。 Vitexin 具有广泛的药理作用,包括抗氧化,抗癌,抗炎,抗痛觉过敏和神经保护作用。

牡荆素名称

[ CAS 号 ]:
3681-93-4

[ 中文名 ]:
牡荆素

[ 英文名 ]:
vitexin

[中文别名 ]:

[英文别名 ]:

8-Glucosylapigenin
vitexin
Apigenin8-C-glucoside
8-b-D-Glucopyranosyl-apigenin
ORIENTOSIDE
Apigenin 8-C-β-D-glucopyranoside
Vitxein
8-D-Glucosyl-4',5,7-trihydroxyflavone
8-β-D-Glucopyranosyl-apigenin
Apigenin 8-C-glucoside

牡荆素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[体内研究]

牡荆素对戊四氮诱导的癫痫发作、东莨菪碱引起的记忆损伤和谷氨酸诱导的神经元兴奋性毒性具有保护作用(1)。

[参考文献]

[1]. He M, et al. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016 Dec;115:74-85.

[2]. Lima LKF, et al. A Brief Review on the Neuroprotective Mechanisms of Vitexin. Biomed Res Int. 2018 Dec 5;2018:4785089.

牡荆素物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
767.7±60.0 °C at 760 mmHg

[ 熔点 ]:
256-257ºC

[ 分子式 ]:
C₂₁H₂₀O₁₀

[ 分子量 ]:
432.378

[ 闪点 ]:
273.1±26.4 °C

[ 精确质量 ]:
432.105652

[ PSA ]:
181.05000

[ LogP ]:
1.28

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.743

[ 储存条件 ]:
室温

牡荆素MSDS

详细MSDS(安全技术说明书)

牡荆素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2984000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-beta-D-glucopyranosyl-2-(4-hydroxyphe nyl)-

CAS REGISTRY NUMBER :: 3681-93-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H20-O10

MOLECULAR WEIGHT :: 432.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD25 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 200 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

牡荆素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DJ2984000

[ 海关编码 ]:
29389090

牡荆素上下游产品

牡荆素上游产品

牡荆素下游产品

牡荆素文献

The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014)

SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that...

Activity-guided isolation, identification and quantification of biologically active isomeric compounds from folk medicinal plant Desmodium adscendens using high performance liquid chromatography with diode array detector, mass spectrometry and multidimentional nuclear magnetic resonance spectroscopy.

J. Pharm. Biomed. Anal. 102 , 54-63, (2014)

The antioxidant activity of the crude extract (60% ethanol) from the leaves of Desmodium adscendens (Sw.) DC. (Fabaceae) was observed in DPPH, xanthine/xanthine oxidase, lipid peroxydation and neutrop...

In vitro and in silico studies to explore structural features of flavonoids for aldehyde oxidase inhibition.

Arch. Pharm. (Weinheim) 347(10) , 738-47, (2014)

Aldehyde oxidase (AO), an important enzyme in the biotransformation of drugs and xenobiotics, is inhibited by flavonoids. This enzyme can metabolize both aldehydes and N-heterocycles. In this work, a ...

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牡荆素