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蔷薇霉素

蔷薇霉素名称

[ CAS 号 ]:
35834-26-5

[ 中文名 ]:
蔷薇霉素

[ 英文名 ]:
rosamicin

[英文别名 ]:

Rosaramicina [INN-Spanish]
Cirramycin A1,4'-deoxy
Antibiotic 67-694
Juvenimicin A3 Rosaramicin
ROSAMICIN
Juvenimicin A3
Rosaramicine [INN-French]
Antibiotic M 4365A2
Rosaramicin
Rosaramicinum [INN-Latin]

蔷薇霉素物理化学性质

[ 密度 ]:
1.17g/cm3

[ 沸点 ]:
734.7ºC at 760mmHg

[ 熔点 ]:
119-122°

[ 分子式 ]:
C₃₁H₅₁NO₉

[ 分子量 ]:
581.73800

[ 闪点 ]:
398.1ºC

[ 精确质量 ]:
581.35600

[ PSA ]:
135.13000

[ LogP ]:
2.67040

[ 折射率 ]:
1.532

蔷薇霉素MSDS

蔷薇霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JG6800000

CHEMICAL NAME :: 4,17-Dioxabicyclo(14.1.0)heptadec-14-ene-10-acetaldeh yde, 3-ethyl-7-hydroxy-2,8,12,16- tetramethyl-5,13-dioxo-9-((3,4,6-trideoxy-3-(dimethyl amino)-beta-D-xylo-he xopyranosyl)oxy)-

CAS REGISTRY NUMBER :: 35834-26-5

LAST UPDATED :: 199509

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C31-H51-N-O9

MOLECULAR WEIGHT :: 581.83

WISWESSER LINE NOTATION :: T3-16- BO FOV OV PUTJ A1 D1 E2 IQ J1 L1VH N1 KO- BT6OTJ CQ DN1&1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,647,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 43,938,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,641,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 155 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,641,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4800 mg/kg/30D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,129,1983

蔷薇霉素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
JG6800000

蔷薇霉素合成路线

蔷薇霉素上下游产品

蔷薇霉素上游产品

蔷薇霉素下游产品

蔷薇霉素文献

A new Micromonospora-produced macrolide antibiotic, rosamicin.

J. Antibiot. 25 , 641, (1972)

Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria.

Antimicrob. Agents Chemother. 57(3) , 1529-31, (2013)

The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by...

Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.

J. Bacteriol. 174(1) , 161-5, (1992)

Cell extracts of Streptomyces antibioticus, an oleandomycin producer, can inactivate oleandomycin in the presence of UDP-glucose. The inactivation can be detected through the loss of biological activi...

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