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布马地宗

布马地宗用途

Bumadizone是一种非甾体抗炎药(NSAID),可以缓解疼痛[1]。

布马地宗名称

[ CAS 号 ]:
3583-64-0

[ 中文名 ]:
布马地宗

[ 英文名 ]:
Bumadizone

[英文别名 ]:

Butyramide,N-sec-butyl
(+-)-Buttersaeure-sec-butylamid
2-[(1,2-Diphenylhydrazino)carbonyl]hexanoic acid
Butanamide,N-(1-methylpropyl)
N-(2-Carboxy-hexanoyl)-hydrazobenzol
N-s-Butyl-butyramide
N-sec-butyl-butyramide
N-(2-carboxycaproyl)hydrazobenzene
N-(2-BUTYL)BUTANAMIDE
Bumadizon (14C)

布马地宗生物活性

[ 描述 ]:

Bumadizone是一种非甾体抗炎药(NSAID),可以缓解疼痛[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

非甾体抗炎药(NSAIDs)广泛用于慢性炎症。

[参考文献]

[1]. Samia A Nour, et al. Bumadizone calcium dihydrate microspheres compressed tablets for colon targeting: formulation, optimization and in vivo evaluation in rabbits. Drug Deliv. 2015 May;22(3):286-97.

布马地宗物理化学性质

[ 密度 ]:
1.227g/cm3

[ 沸点 ]:
487.4ºC at 760mmHg

[ 分子式 ]:
C₁₉H₂₂N₂O₃

[ 分子量 ]:
326.39000

[ 闪点 ]:
248.6ºC

[ 精确质量 ]:
326.16300

[ PSA ]:
69.64000

[ LogP ]:
4.01070

[ 折射率 ]:
1.628

布马地宗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO0623000

CHEMICAL NAME :: Malonic acid, butyl-, mono(1,2-diphenylhydrazide)

CAS REGISTRY NUMBER :: 3583-64-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H22-N2-O3

MOLECULAR WEIGHT :: 326.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67,337,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67,337,1971

布马地宗安全信息

[ 海关编码 ]:
2928000090

布马地宗合成路线

详细合成路线

布马地宗上下游产品

布马地宗上游产品

布马地宗下游产品

布马地宗海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%