氰美马嗪
氰美马嗪用途
氰美马嗪名称
[ CAS 号 ]:
3546-03-0
[ 中文名 ]:
氰美马嗪
[ 英文名 ]:
Cyamemazine
[英文别名 ]:
- Kyamepromazin
- Kyamepromazine
- 7204 R.E.
- Ciamatil
- Cyamemazine
- Tercian
氰美马嗪生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
5-HT2A Receptor:1.5 nM (Ki)
5-HT2C Receptor:12 nM (Ki)
5-HT3 Receptor:75 nM (Ki)
[体外研究]
[体内研究]
[参考文献]
氰美马嗪物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
479.0±45.0 °C at 760 mmHg
[ 分子式 ]:
C19H21N3S
[ 分子量 ]:
323.455
[ 闪点 ]:
243.5±28.7 °C
[ 精确质量 ]:
323.145630
[ PSA ]:
55.57000
[ LogP ]:
4.62
[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C
[ 折射率 ]:
1.655
[ 储存条件 ]:
2-8°C, 密封, 干燥
氰美马嗪MSDS
氰美马嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SN6950000
- CHEMICAL NAME :
- Phenothiazine-2-carbonitrile, 10-(3-(dimethylamino)-2-methylpropyl)-
- CAS REGISTRY NUMBER :
- 3546-03-0
- BEILSTEIN REFERENCE NO. :
- 0093261
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H21-N3-S
- MOLECULAR WEIGHT :
- 323.49
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B1Y1&1N1&1 ECN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982
- TYPE OF TEST :
- Rinsed with water
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 107 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 17,386,1993
氰美马嗪安全信息
[ 符号 ]:
GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H410
[ 警示性声明 ]:
P273-P501
[ 危害码 (欧洲) ]:
Xi
[ 危险品运输编码 ]:
UN 3077 9 / PGIII
[ 海关编码 ]:
2934300000
氰美马嗪合成路线
氰美马嗪上下游产品
氰美马嗪上游产品
氰美马嗪下游产品
氰美马嗪海关
[ 海关编码 ]: 2934300000
[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
氰美马嗪文献
Int. J. Legal Med. 129(2) , 259-68, (2015)
Despite a non-invasive sampling, hair samples are generally collected in limited amounts for an obvious esthetic reason. In order to reduce the required quantity of samples, a multianalytes method all...
Fatal intoxication with milnacipranJ. Forensic Leg. Med. 15(6) , 388-90, (2008)
The antidepressant milnacipran is a double serotonin/noradrenalin reuptake inhibitor. The low reported incidence of intoxication indicates excellent tolerance in comparison with tricyclic and second g...
Prise en charge médicamenteuse de l’anxiété chez le patient souffrant de schizophrénieEncephale 37 Suppl 1 , S83-9, (2011)
L’anxiété est un symptôme fréquent et majeur de la schizophrénie. Elle est un symptôme clinique dominant dans la phase prodromique [indice de progression vers la « décompensation psychotique »] et acc...
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