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17-十八炔酸

17-十八炔酸用途

Alkynyl Stearic Acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

17-十八炔酸名称

[ CAS 号 ]:
34450-18-5

[ 中文名 ]:
17-十八炔酸

[ 英文名 ]:
17-ODYA

[英文别名 ]:

Octadec-17-ynoic acid
17-Octadecynoic acid
MFCD00077382

17-十八炔酸生物活性

[ 描述 ]:

Alkynyl Stearic Acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

17-十八炔酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
400.8±18.0 °C at 760 mmHg

[ 熔点 ]:
142-148 °C(lit.)

[ 分子式 ]:
C₁₈H₃₂O₂

[ 分子量 ]:
280.445

[ 闪点 ]:
194.7±15.9 °C

[ 精确质量 ]:
280.240234

[ PSA ]:
37.30000

[ LogP ]:
6.86

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.470

[ 储存条件 ]:
Store at RT

17-十八炔酸MSDS

17-十八炔酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2916190090

17-十八炔酸合成路线

17-十八炔酸上下游产品

17-十八炔酸上游产品

17-十八炔酸下游产品

17-十八炔酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

17-十八炔酸文献

Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.

Proteomics 15 , 2066-77, (2015)

Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane i...

Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.

Int. J. Obes. 39 , 755-61, (2015)

Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-...

Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.

Drug Metab. Pharmacokinet. 26(3) , 300-6, (2011)

The oral bioavailability of some drugs is markedly lower in cynomolgus monkeys than in humans. One of the reasons for the low bioavailability in cynomolgus monkeys may be the higher metabolic activity...

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