匹凡西林
匹凡西林用途
匹匹西林是一种青霉素类抗生素。匹匹西林是氨苄青霉素(HY-B0522)的前药[1]。
匹凡西林名称
[ CAS 号 ]:
33817-20-8
[ 中文名 ]:
匹凡西林
[ 英文名 ]:
pivampicillin
[中文别名 ]:
[英文别名 ]:
- Pivampicillin
- Pivaloyloxymethyl ampicillinate
- Pivampicilline
- Pondocillin
- Pivampicilina
- Pivampicillinum
- Pivaloylampicillin
- Ampicillin pivaloyloxymethyl ester
匹凡西林生物活性
匹凡西林物理化学性质
[ 密度 ]:
1.33g/cm3
[ 沸点 ]:
679ºC at 760mmHg
[ 分子式 ]:
C22H29N3O6S
[ 分子量 ]:
463.55
[ 闪点 ]:
364.5ºC
[ 精确质量 ]:
463.17800
[ PSA ]:
153.33000
[ LogP ]:
2.35260
[ 折射率 ]:
1.604
[ 水溶解性 ]:
Practically insoluble in water, freely soluble in methanol, soluble in anhydrous ethanol. It dissolves in dilute acids.
匹凡西林毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XH8380000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)-3,3- dimethyl-7-oxo-, hydroxymethyl ester, pivalate (ester), D-(-)-
- CAS REGISTRY NUMBER :
- 33817-20-8
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C22-H29-N3-O6-S
- MOLECULAR WEIGHT :
- 463.60
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ CMVYZR& F1 F1 GVO1OVX1&1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 900 mg/kg/90D-I
- TOXIC EFFECTS :
- Behavioral - muscle weakness Musculoskeletal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 68,932,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >6 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,310,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 148 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,310,1978
匹凡西林合成路线
匹凡西林上下游产品
匹凡西林上游产品
匹凡西林下游产品
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