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红霉素A烯醇醚

红霉素A烯醇醚用途

Erythromycin A enol ether 是一种 Erythromycin A(大环内酯抗生素)的酸性降解产物,无抗菌作用。

红霉素A烯醇醚名称

[ CAS 号 ]:
33396-29-1

[ 中文名 ]:
红霉素A烯醇醚

[ 英文名 ]:
Erythromycin A Enol Ether

[英文别名 ]:

8,9-anhydroerythromycin A 6,9-hemiacetal
8,9-anhydroerythromycin A 6,9-hemiketal
erythromycin hemiketal
8,9-anhydroerythromycin 6,9-hemiketal
8,9-anhydroerythromycin A
EM 523
Erythromycin Impurity 5

红霉素A烯醇醚生物活性

[ 描述 ]:

Erythromycin A enol ether 是一种 Erythromycin A(大环内酯抗生素)的酸性降解产物,无抗菌作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. A Deubel, et al. Development of an enhanced separation of erythromycin and its related substances by liquid chromatography. J Pharm Biomed Anal. 2007 Jan 17;43(2):493-8.

[2]. Abdolreza Hassanzadeh, et al. Mechanism for the degradation of erythromycin A and erythromycin A 2'-ethyl succinate in acidic aqueous solution. J Phys Chem A. 2007 Oct 11;111(40):10098-104.

红霉素A烯醇醚物理化学性质

[ 密度 ]:
1.2g/cm3

[ 沸点 ]:
791.6ºC at 760mmHg

[ 熔点 ]:
133-135ºC

[ 分子式 ]:
C₃₇H₆₅NO₁₂

[ 分子量 ]:
715.91100

[ 闪点 ]:
432.6ºC

[ 精确质量 ]:
715.45100

[ PSA ]:
165.84000

[ LogP ]:
2.89230

[ 折射率 ]:
1.542

[ 储存条件 ]:
-20°C Freezer

红霉素A烯醇醚安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

红霉素A烯醇醚合成路线

详细合成路线

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红霉素A烯醇醚文献

Sensitive high-performance liquid chromatographic determination of EM523, a new erythromycin derivative, in human plasma and urine with ultraviolet detection using column switching.

J. Chromatogr. A. 616(1) , 144-50, (1993)

A sensitive high-performance liquid chromatographic (HPLC) method using column switching is described for the determination of EM523 (I), a new erythromycin derivative, in human plasma and urine. The ...

Comparison of the motor-stimulating action of EM523, an erythromycin derivative, and prostaglandin F2 alpha in conscious dogs.

Jpn. J. Pharmacol. 63(2) , 209-17, (1993)

The effect of EM523 [de(N-methyl)-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal], an erythromycin derivative, on gastrointestinal motility was investigated using conscious dogs in the fasting state...

EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion.

Peptides 17(6) , 895-900, (1996)

We investigated the efficacy and the mechanism of action of EM523L, a nonpeptide motilin agonist (motilide), on the stimulation of gastric emptying and on the release of gut peptides after ingestion o...

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