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对三氟甲基水杨酸

对三氟甲基水杨酸用途

4-三氟甲基水杨酸(三氟脱乙酰基)是一种血小板聚集抑制剂[1]。

对三氟甲基水杨酸名称

[ CAS 号 ]:
328-90-5

[ 中文名 ]:
4-三氟甲基水杨酸

[ 英文名 ]:
4-Trifluoromethylsalicylic acid

[中文别名 ]:

[英文别名 ]:

Benzoic acid, 2-hydroxy-4-(trifluoromethyl)-
QVR BQ DXFFF
2-Hydroxy-4-(trifluoromethyl)benzoic acid
MFCD01529657
4-Trifluoromethylsalicylic acid
4-Trifluoromethyl Salicylic Acid
2-hydroxy-4-trifluoromethyl benzoic acid
Triflusal impurity B
4-(TrifluoroMethyl)salicylic Acid
4-Tfmsa

对三氟甲基水杨酸生物活性

[ 描述 ]:

4-三氟甲基水杨酸(三氟脱乙酰基)是一种血小板聚集抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Rodríguez G, et al. Hydrophilic polymer drug from a derivative of salicylic acid: synthesis, controlled release studies and biological behavior. Macromol Biosci. 2004;4(6):579-586.

对三氟甲基水杨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
286.4±40.0 °C at 760 mmHg

[ 熔点 ]:
178ºC

[ 分子式 ]:
C₈H₅F₃O₃

[ 分子量 ]:
206.119

[ 闪点 ]:
127.0±27.3 °C

[ 精确质量 ]:
206.019073

[ PSA ]:
57.53000

[ LogP ]:
4.16

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.510

[ 储存条件 ]:
室温

对三氟甲基水杨酸MSDS

对三氟甲基水杨酸安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 海关编码 ]:
2918290000

对三氟甲基水杨酸合成路线

对三氟甲基水杨酸上下游产品

对三氟甲基水杨酸上游产品

对三氟甲基水杨酸下游产品

对三氟甲基水杨酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

对三氟甲基水杨酸文献

The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.

Eur. J. Pharm. Sci. 31(3-4) , 211-20, (2007)

In this research, the effects of micellar systems on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) were found to be dependant upon the surfactant charge within the mi...

A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.

Expert Opin. Drug Metab. Toxicol. 7(12) , 1471-9, (2011)

An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compa...

Salicylates increase insulin secretion in healthy obese subjects.

J. Clin. Endocrinol. Metab. 93(7) , 2523-30, (2008)

Conflicting results on the effects of salicylates on glucose tolerance in subjects with normal glucose tolerance or type 2 diabetes have been reported.The objective of the study was to investigate the...

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