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己芴溴铵

己芴溴铵用途

二溴六氟(Mylasen)是一种有效的胆碱酯酶(ChE)抑制剂,其pI50值为6.96,Ki值为2.4nM,适用于人血浆胆碱酯酯酶(ChE)[1]。

己芴溴铵名称

[ CAS 号 ]:
317-52-2

[ 中文名 ]:
己芴溴铵

[ 英文名 ]:
Hexafluronium Bromide

[英文别名 ]:

Esafluronio bromuro
Milaxen
Hexafluorenium dibromide
hexafluorenium bromide
Hexafluroniumbromid
hexafluorenium
Hexafluronii bromidum
Hexafluronium bromide
Mylaxen

己芴溴铵生物活性

[ 描述 ]:

二溴六氟(Mylasen)是一种有效的胆碱酯酶(ChE)抑制剂,其pI50值为6.96,Ki值为2.4nM,适用于人血浆胆碱酯酯酶(ChE)[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

己芴溴铵物理化学性质

[ 分子式 ]:
C₃₆H₄₂Br₂N₂

[ 分子量 ]:
662.54000

[ 精确质量 ]:
660.17100

[ LogP ]:
2.24760

己芴溴铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BQ8225000

CHEMICAL NAME :: Ammonium, hexamethylenebis(fluoren-9-yldimethyl-, dibromide

CAS REGISTRY NUMBER :: 317-52-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C36-H42-N2.2Br

MOLECULAR WEIGHT :: 662.62

WISWESSER LINE NOTATION :: L B656 HHJ HK1&1&6K1&1&- HL B656 HHJ &E 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 400 ug/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: 85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85 Volume(issue)/page/year: 1,E1,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,603,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,603,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1760 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 2,233,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,200,1959

己芴溴铵安全信息

[ 海关编码 ]:
2923900090

己芴溴铵合成路线

详细合成路线

己芴溴铵上下游产品

己芴溴铵上游产品

己芴溴铵下游产品

己芴溴铵海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%