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磷酸异丙烟肼

磷酸异丙烟肼用途

Iproniazid是一种非选择性的,不可逆的单胺氧化酶抑制剂 (MAOI)。

磷酸异丙烟肼名称

[ CAS 号 ]:
305-33-9

[ 中文名 ]:
磷酸异丙烟肼

[ 英文名 ]:
Iproniazid (phosphate)

[中文别名 ]:

[英文别名 ]:

4-pyridinecarboxylic acid
iproniaziddihydrogenphosphate
IPRONIAZID PHOSPHATE SALT
N'-Isopropylisonicotinohydrazide phosphate
1-Isonicotinyl-2-isopropylhydrazine Phosphate
Iproniazidphosphat
phosphate (1:1)
ISONICOTINIC ACID 2-ISOPROPYLHYDRAZIDE PHOSPHATE
IPRONIAZID PHOSP
marsilidphosphate

磷酸异丙烟肼生物活性

[ 描述 ]:

Iproniazid是一种非选择性的,不可逆的单胺氧化酶抑制剂 (MAOI)。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

[参考文献]

[1]. Robert A,et al. Drug discovery. Humana Press. pp. 143–154.

[2]. Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8): 1381–1387

[相关活性小分子]

磷酸异丙烟肼物理化学性质

[ 密度 ]:
1.084g/cm3

[ 沸点 ]:
265.9ºC at 760mmHg

[ 熔点 ]:
181ºC

[ 分子式 ]:
C₉H₁₆N₃O₅P

[ 分子量 ]:
277.21400

[ 闪点 ]:
114.6ºC

[ 精确质量 ]:
277.08300

[ PSA ]:
141.59000

[ LogP ]:
0.57760

[ 储存条件 ]:
2-8°C

磷酸异丙烟肼MSDS

详细MSDS(安全技术说明书)

磷酸异丙烟肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS1950000

CHEMICAL NAME :: Isonicotinic acid, 2-isopropylhydrazide, phosphate

CAS REGISTRY NUMBER :: 305-33-9

LAST UPDATED :: 199803

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H13-N3-O.H3-O4-P

MOLECULAR WEIGHT :: 277.25

WISWESSER LINE NOTATION :: T6NJ DVMMY1&1 &QPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 442 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 730 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 130 mg/kg

SEX/DURATION :: female 10-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 640 mg/kg

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982

磷酸异丙烟肼安全信息

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
23/24/25

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 3249

[ RTECS号 ]:
NS1950000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933399090

磷酸异丙烟肼海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%