1,2,3,4-四氢-2-萘胺

1,2,3,4-四氢-2-萘胺名称

[ CAS 号 ]:
2954-50-9

[ 中文名 ]:
1,2,3,4-四氢-2-萘胺

[ 英文名 ]:
2-Aminotetralin

[中文别名 ]:

1,2,3,4-四氢-2-氨基萘

[英文别名 ]:

1-Naphthalenol,1,2,3,4-tetrahydro-,benzoate
1-Benzoyloxy-1.2.3.4-tetrahydro-naphthalin
1,2,3,4-tetrahydronaphth-2-ylamine
2-Aminotetralin
Aminotetralin
1,2,3,4-tetrahydronaphthalen-1-yl benzoate
2-amino-1,2,3,4-tetrahydronaphthalene
1,2,3,4-Tetrahydro-2-naphthalenamine
2-amino-tetralin
2-R-amino-tetraline

1,2,3,4-四氢-2-萘胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
250.7±29.0 °C at 760 mmHg

[ 熔点 ]:
149-151 °C

[ 分子式 ]:
C₁₀H₁₃N

[ 分子量 ]:
147.217

[ 闪点 ]:
111.6±19.6 °C

[ 精确质量 ]:
147.104797

[ PSA ]:
26.02000

[ LogP ]:
2.09

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
-20°C，密封，干燥，避光

1,2,3,4-四氢-2-萘胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QM4900000

CHEMICAL NAME :: 2-Naphthylamine, 1,2,3,4-tetrahydro-

CAS REGISTRY NUMBER :: 2954-50-9

BEILSTEIN REFERENCE NO. :: 1102357

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H13-N

MOLECULAR WEIGHT :: 147.24

WISWESSER LINE NOTATION :: L66&TJ HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,466,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,466,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - sleep Behavioral - hallucinations, distorted perceptions

REFERENCE :: APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - sleep Behavioral - hallucinations, distorted perceptions

REFERENCE :: APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,168,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Vascular - regional or general arteriolar constriction Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,70,1928

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,168,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 20 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - stillbirth

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959

1,2,3,4-四氢-2-萘胺安全信息

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 海关编码 ]:
2921450090

1,2,3,4-四氢-2-萘胺合成路线

详细合成路线

1,2,3,4-四氢-2-萘胺上下游产品

1,2,3,4-四氢-2-萘胺上游产品

1,2,3,4-四氢-2-萘胺下游产品

1,2,3,4-四氢-2-萘胺海关

[ 海关编码 ]: 2921450090

[ 中文概述 ]:
2921450090. 1-萘胺和2-萘胺的衍生物及盐(包括1-萘胺）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921450090 1-naphthylamine (α-naphthylamine), 2-naphthylamine (β-naphthylamine) and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%