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轮环藤宁

轮环藤宁用途

Cyclen 是氮杂冠醚的类似物,为制备磁共振造影剂的前体物质,同时为制备有效的大环螯合物的中间体。

轮环藤宁名称

[ CAS 号 ]:
294-90-6

[ 中文名 ]:
1,4,7,10-四氮杂环十二烷

[ 英文名 ]:
Cyclen

[中文别名 ]:

[英文别名 ]:

Tetraaza-12-crown-4
T-12-M DM GM JMTJ
Cyclen
1,4,7,10-tetrazacyclododecane
MFCD00066281
1,4,7,10-Tetraazacyclododecane
5-26-11-00023 (Beilstein Handbook Reference)
[12]aneN4
1,4,7,12-tetraazacyclodedecane
EINECS 202-928-3

轮环藤宁生物活性

[ 描述 ]:

Cyclen 是氮杂冠醚的类似物,为制备磁共振造影剂的前体物质,同时为制备有效的大环螯合物的中间体。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684.

轮环藤宁物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
283.8±8.0 °C at 760 mmHg

[ 熔点 ]:
110-113 °C(lit.)

[ 分子式 ]:
C₈H₂₀N₄

[ 分子量 ]:
172.27

[ 闪点 ]:
129.5±13.5 °C

[ 精确质量 ]:
172.168793

[ PSA ]:
48.12000

[ LogP ]:
-2.34

[ 外观性状 ]:
灰白色至略黄色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.424

[ 储存条件 ]:
Refrigerator

轮环藤宁MSDS

轮环藤宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XA5253000

CHEMICAL NAME :: 1,4,7,10-Tetraazacyclododecane

CAS REGISTRY NUMBER :: 294-90-6

BEILSTEIN REFERENCE NO. :: 0606114

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H20-N4

MOLECULAR WEIGHT :: 172.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 388 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 70,201,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 19,425,1984

轮环藤宁安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H312-H314-H410

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XA5253000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
2933990090

轮环藤宁合成路线

轮环藤宁上下游产品

轮环藤宁上游产品

轮环藤宁下游产品

轮环藤宁海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

轮环藤宁文献

Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.

Bioorg. Med. Chem. Lett. 18 , 169-74, (2008)

Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neur...

Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation.

Inorg. Chem. 51(12) , 6916-27, (2012)

The syntheses of a new 1,4,7,10-tetraazacyclododecane (cyclen) derivative bearing a picolinate pendant arm (HL1), and its 1,4,8,11-tetraazacyclotetradecane (cyclam) analogue HL2, were achieved by usin...

Copper and cobalt complexes of octadentate azamacrocycles: spectrophotometric titration, stopped-flow kinetics and crystallographic study.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1) , 525-31, (2011)

Details of complex formation kinetics are reported for tetrakis(2-hydroxyethyl) substituted cyclen (L(1)) and cyclam (L(2)) with Cu(II) and Co(II). Stopped-flow kinetics and spectroscopic titration me...

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