2-(4-甲基-1-哌嗪基)-喹啉

2-(4-甲基-1-哌嗪基)-喹啉用途

N-Methylquipazine is a 5-HT3 agonist. Has almost the same affinity for 5-HT3 sites as quipazine but unlike the latter, does not bind to 5-HT1B sites.

2-(4-甲基-1-哌嗪基)-喹啉名称

[ CAS 号 ]:
28614-26-8

[ 中文名 ]:
2-(4-甲基-1-哌嗪基)-喹啉

[ 英文名 ]:
N-Methylquipazine

[英文别名 ]:

N-Methylquipazine dimaleate salt
N-Methylquipazine
N-METHYLQUIPAZINE DIMALEATE
QUIPAZINE,N-METHYL-DIMALEATE

2-(4-甲基-1-哌嗪基)-喹啉物理化学性质

[ 分子式 ]:
C₂₂H₂₅N₃O₈

[ 分子量 ]:
459.44900

[ 精确质量 ]:
459.16400

[ PSA ]:
168.57000

[ LogP ]:
1.41310

2-(4-甲基-1-哌嗪基)-喹啉安全信息

[ 海关编码 ]:
2933990090

2-(4-甲基-1-哌嗪基)-喹啉海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(4-甲基-1-哌嗪基)-喹啉文献

Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study.

Eur. J. Pharmacol. 168 , 387-392, (1989)

The binding affinities of a series of arylpiperazine derivatives at [3H]quipazine-labeled central 5-HT3 sites were investigated. Features determined to be important for binding include the N4 piperazi...

The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study.

Synapse 24 , 313, (1996)

In this study, we examined the effect of n-methylquipazine (NMQ), which is a putative 5-hydroxytryptamine3(5-HT3)receptor agonist, on the extracellular concentrations of dopamine (DA) and one of its m...

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