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荭草素

荭草素用途

Orientin 是一种天然存在的生物活性类黄酮,具有多种生物特性,包括抗炎、抗氧化、抗肿瘤、保护心脏等。Orientin 是一种有前景的神经保护剂,适用于神经性疼痛的治疗。

荭草素名称

[ CAS 号 ]:
28608-75-5

[ 中文名 ]:
荭草苷

[ 英文名 ]:
Orientin

[中文别名 ]:

荭草素

[英文别名 ]:

isoorientin
Orientin 8-C-β-D-glucopyranoside
3',4',5,7-tetrahydroxyflavone-8-C-glucoside
Luteolin-8-C-glucoside
3',4',5,7-tetrahydroxyflavone 8-glucoside
Orientin
lutexin

荭草素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Dhakal H, et al. Inhibitory effects of orientin in mast cell-mediated allergic inflammation. Pharmacol Rep. 2020 Jan 24.

[2]. Guo D, et al. Orientin and neuropathic pain in rats with spinal nerve ligation. 61Int Immunopharmacol. 2018 May;58:72-79.

荭草素物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
816.1±65.0 °C at 760 mmHg

[ 熔点 ]:
260-285ºC

[ 分子式 ]:
C₂₁H₂₀O₁₁

[ 分子量 ]:
448.377

[ 闪点 ]:
289.1±27.8 °C

[ 精确质量 ]:
448.100555

[ PSA ]:
201.28000

[ LogP ]:
1.58

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.767

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
1 M NaOH: soluble1mg/mL, clear, yellow-orange

荭草素MSDS

详细MSDS(安全技术说明书)

荭草素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3009300

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-d ihydroxy-

CAS REGISTRY NUMBER :: 28608-75-5

LAST UPDATED :: 199106

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H20-O11

MOLECULAR WEIGHT :: 448.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

荭草素安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DJ3009300

荭草素文献

Distinction of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin using HPLC-MS exact mass measurement and in-source CID.

Phytochem. Anal. 16(5) , 295-301, (2005)

HPLC-MS using collision induced dissociation (CID) has been utilised for the identification of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin. HPLC-CID/MS analyses prod...

Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats.

Pharm. Biol. 50(11) , 1428-35, (2012)

Lagenaria siceraria (Molina) Standl. (Cucurbitacae) (LS) has been reported to possess cardioprotective, antihyperlipidemic, and diuretic activities.To evaluate antihypertensive and cardioprotective ef...

Development and validation of an HPTLC method for simultaneous quantitation of isoorientin, isovitexin, orientin, and vitexin in bamboo-leaf flavonoids.

J. AOAC Int. 93(5) , 1376-83, (2010)

A simple HPTLC method has been developed for the simultaneous determination of isoorientin, isovitexin, orientin, and vitexin, both pure and in commercial samples of bamboo-leaf flavonoids. The flavon...

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荭草素