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肠杆菌素

肠杆菌素用途

Enterobactin 是一种可促进铁吸收的细菌铁载体,可用于炎症的研究。Enterobactin 还破坏巨噬细胞 (MΦs) 铁稳态和 M1/M2 极化,以保护细胞内细菌免受宿主的抗菌作用。

肠杆菌素名称

[ CAS 号 ]:
28384-96-5

[ 中文名 ]:
肠杆菌素

[ 英文名 ]:
Enterobactin from Escherichia coli

[英文别名 ]:

Enterobactin

肠杆菌素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Saha P, et al. The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages. Gut Microbes. 2019;10(3):412-423.

肠杆菌素物理化学性质

[ 密度 ]:
1.72g/cm3

[ 沸点 ]:
1109.1ºC at 760 mmHg

[ 熔点 ]:
202-203°C (lit.)

[ 分子式 ]:
C₃₀H₂₇N₃O₁₅

[ 分子量 ]:
669.54600

[ 闪点 ]:
624.6ºC

[ 精确质量 ]:
669.14400

[ PSA ]:
298.05000

[ LogP ]:
0.98340

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.732

[ 储存条件 ]:
20°C

肠杆菌素安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

肠杆菌素文献

The C-glycosyltransferase IroB from pathogenic Escherichia coli: identification of residues required for efficient catalysis.

Biochim. Biophys. Acta 1844(9) , 1619-30, (2014)

Escherichia coli C-glycosyltransferase IroB catalyzes the formation of a CC bond between enterobactin and the glucose moiety of UDP-glucose, resulting in the production of mono-, di- and tri-glucosyla...

Human Urinary Composition Controls Antibacterial Activity of Siderocalin.

J. Biol. Chem. 290 , 15949-60, (2015)

During Escherichia coli urinary tract infections, cells in the human urinary tract release the antimicrobial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-associated lipoc...

AhpC is required for optimal production of enterobactin by Escherichia coli.

J. Bacteriol. 194(24) , 6748-57, (2012)

Escherichia coli alkyl hydroperoxide reductase subunit C (AhpC) is a peroxiredoxin that detoxifies peroxides. Here we show an additional role for AhpC in cellular iron metabolism of E. coli. Deletion ...

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