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羟基乙叉二膦酸(HEDP)

羟基乙叉二膦酸(HEDP)用途

Etidronic acid是一种应用于洗涤,水处理,化妆品和制药业的双磷酸盐。

羟基乙叉二膦酸(HEDP)名称

[ CAS 号 ]:
2809-21-4

[ 中文名 ]:
羟基乙叉二膦酸

[ 英文名 ]:
Etidronic acid

[中文别名 ]:

[英文别名 ]:

(1-Hydroxyethane-1,1-diyl)diphosphonic acid
Etidronsaeure
Acetodiphosphonic acid
ethane-1-hydroxy-1,1-diphosphonic acid
MFCD00070585
1-hydroxyethane 1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
EHDP
Phosphonic acid, (1-hydroxyethylidene)bis-
Osteoscan

羟基乙叉二膦酸(HEDP)生物活性

[ 描述 ]:

Etidronic acid是一种应用于洗涤,水处理,化妆品和制药业的双磷酸盐。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[参考文献]

[1]. http://www.truthinaging.com/ingredients/etidronic-acid

[相关活性小分子]

羟基乙叉二膦酸(HEDP)物理化学性质

[ 密度 ]:
2.1±0.1 g/cm3

[ 沸点 ]:
578.8±60.0 °C at 760 mmHg

[ 熔点 ]:
198~199℃

[ 分子式 ]:
C₂H₈O₇P₂

[ 分子量 ]:
206.028

[ 闪点 ]:
303.8±32.9 °C

[ 精确质量 ]:
205.974518

[ PSA ]:
154.91000

[ LogP ]:
-3.54

[ 外观性状 ]:
淡米色粉末

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.586

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

羟基乙叉二膦酸(HEDP)MSDS

羟基乙叉二膦酸(HEDP)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ8562100

CHEMICAL NAME :: Phosphonic acid, (1-hydroxyethylidene)di-

CAS REGISTRY NUMBER :: 2809-21-4

BEILSTEIN REFERENCE NO. :: 1789291

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C2-H8-O7-P2

MOLECULAR WEIGHT :: 206.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 50,879,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)

REFERENCE :: JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 20,91,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 19,87,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 49,837,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),16A,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1400 mg/kg

SEX/DURATION :: female 11-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 22,47,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0985 No. of Facilities: 404 (estimated) No. of Industries: 10 No. of Occupations: 7 No. of Employees: 6655 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0985 No. of Facilities: 3273 (estimated) No. of Industries: 73 No. of Occupations: 46 No. of Employees: 44885 (estimated) No. of Female Employees: 3814 (estimated)

羟基乙叉二膦酸(HEDP)安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H290-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
37/38-41

[ 安全声明 (欧洲) ]:
S26-S39

[ 危险品运输编码 ]:
UN 3265

[ WGK德国 ]:
2

[ RTECS号 ]:
SZ8562100

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2931900090

羟基乙叉二膦酸(HEDP)合成路线

羟基乙叉二膦酸(HEDP)上下游产品

羟基乙叉二膦酸(HEDP)上游产品

羟基乙叉二膦酸(HEDP)下游产品

羟基乙叉二膦酸(HEDP)制备

1.由三氯化磷与冰醋酸混合后，加热、蒸馏，得乙酰氯（见00510），再与亚磷酸反应制得。市售品为以水稀释为含量50%的粘稠液体。每吨产品消耗三氯化磷（95%）931kg，冰醋酸591kg。

2.由三氯化磷、冰乙酸和水反应制得。或者由正磷酸、乙酐和乙酰氯反应制得。也可以由亚磷酸和乙酐反应制得。还可以由正磷酸和乙酐反应。

3.工业上通常采用冰醋酸与三氯化磷酰基化，再由酰基化产物与三氯化磷水解产物缩合法。将计量的水，冰醋酸加入反应釜中，搅拌均匀。在冷却下滴加三氯化磷，控制反应温度在40～80℃。反应副产物氯化氢气体经冷凝后送入吸收塔，回收盐酸。溢出的乙酰氯和醋酸经冷凝仍回反应器。滴完三氯化磷后，升温至100～130℃，回流4 ～5h 。反应结束后，通水蒸气水解，蒸出残留的醋酸及低沸点物。得产品。反应式如下：

4.通过二乙烯三胺与甲醛的亲核加成，加成产物与三氯化磷水解产物酯化，中和得产品。

羟基乙叉二膦酸(HEDP)海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

羟基乙叉二膦酸(HEDP)文献

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.

Biochim. Biophys. Acta 1841(7) , 977-86, (2014)

2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cho...

FDA-approved drug labeling for the study of drug-induced liver injury.

Drug Discov. Today 16 , 697-703, (2011)

Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effec...

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