四氢酞酰亚胺

四氢酞酰亚胺用途

本品用作浅色醇酸树脂、气干性水溶树脂、原子灰树脂、PE树脂、涂料、环氧树脂固化剂、聚酯树脂、F级绝缘材料、胶黏剂、增塑剂等。

本品为化工原料中间体，可用作生产农药敌菌丹、克菌丹等及增塑剂、黏合剂。

四氢酞酰亚胺名称

[ CAS 号 ]:
27813-21-4

[ 中文名 ]:
四氢酞酰亚胺

[ 英文名 ]:
cis-1,2,3,6-Tetrahydrophthalimide

[中文别名 ]:

[英文别名 ]:

EINECS 215-999-0
CIS-1,2,3,6-TETRAHYDROPHTHALIMIDE,5GM,NEAT
CIS-1,2,3,6-tetrahudrophthalimide
4,5,6,7-Tetrahydroisoindole-1,3-dione
cis-4-Cyclohexene-1,2-dicarboximide
TETRAHYDROTHALIMIDE
Phthalimide,tetrahydro

四氢酞酰亚胺物理化学性质

[ 密度 ]:
1.27 g/cm3

[ 沸点 ]:
392ºC

[ 熔点 ]:
129-133 °C(lit.)

[ 分子式 ]:
C₈H₉NO₂

[ 分子量 ]:
151.16300

[ 闪点 ]:
158.1ºC

[ 精确质量 ]:
151.06300

[ PSA ]:
46.17000

[ LogP ]:
0.55400

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.000247mmHg at 25°C

[ 折射率 ]:
1.559

四氢酞酰亚胺MSDS

详细MSDS(安全技术说明书)

四氢酞酰亚胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GW4635000

CHEMICAL NAME :: Cyclohexene-1,2-dicarboximide

CAS REGISTRY NUMBER :: 27813-21-4

BEILSTEIN REFERENCE NO. :: 0136336

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

WISWESSER LINE NOTATION :: T56 BVMV&TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >150 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >150 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1525 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 825 mg/kg

SEX/DURATION :: female 6-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 13,420,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,24,1970

四氢酞酰亚胺安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21

[ 安全声明 (欧洲) ]:
S24/25-S36/37/39-S7

[ WGK德国 ]:
3

[ RTECS号 ]:
GW4635000

四氢酞酰亚胺制备

将顺丁烯二酸酐加入反应釜，加热至全部熔融后，搅拌下加入溶剂苯，搅拌混溶后，继续搅拌并加热升温至100～110℃，通入C4馏分或丁二烯进行双烯加成反应。反应结束后将溶剂苯蒸出，经冷凝器冷却后回收循环使用。反应液经抽滤、干燥,即得成品。顺丁烯二酸酐的转化率可达100%。