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1,2-亚甲二氧基苯

1,2-亚甲二氧基苯用途

【用途一】
用作重要的香料、医药及农药中间体
【用途二】
有机合成中间体。用于合成黄连素。
【用途三】
有机合成中间体。用于合成黄连素

1,2-亚甲二氧基苯名称

[ CAS 号 ]:
274-09-9

[ 中文名 ]:
1,3-苯并间二氧杂环戊烯

[ 英文名 ]:
1,3-Benzodioxole

[中文别名 ]:

[英文别名 ]:

MFCD00005818
EINECS 205-992-0
Methylenedioxy benzene
1,3-Benzodioxole
1,2-Methylenedioxybenzene
3,4-Methylenedioxybenzene
T56 BO DO CHJ
Benzo[d][1,3]dioxole
1,2-(Methylenedioxy)benzene
1,3-benzodioxolan

1,2-亚甲二氧基苯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
173.0±15.0 °C at 760 mmHg

[ 熔点 ]:
-18 °C

[ 分子式 ]:
C₇H₆O₂

[ 分子量 ]:
122.121

[ 闪点 ]:
55.0±0.0 °C

[ 精确质量 ]:
122.036781

[ PSA ]:
18.46000

[ LogP ]:
2.08

[ 外观性状 ]:
透明无色至淡黄色液体

[ 蒸汽压 ]:
1.7±0.3 mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
0.2 g/100 mL (25 ºC)

1,2-亚甲二氧基苯MSDS

1,2-亚甲二氧基苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA5600000

CHEMICAL NAME :: Benzene, 1,2-methylenedioxy-

CAS REGISTRY NUMBER :: 274-09-9

BEILSTEIN REFERENCE NO. :: 0115506

LAST UPDATED :: 199803

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H6-O2

MOLECULAR WEIGHT :: 122.13

WISWESSER LINE NOTATION :: T56 BO DO CHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,18,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Skin and Appendages - hair

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg/60D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,18,1965

1,2-亚甲二氧基苯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H332

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R10;R22

[ 安全声明 (欧洲) ]:
S23-S24/25-S36/37/39-S26-S16

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DA5600000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29329970

1,2-亚甲二氧基苯合成路线

1,2-亚甲二氧基苯上下游产品

1,2-亚甲二氧基苯上游产品

1,2-亚甲二氧基苯下游产品

1,2-亚甲二氧基苯制备

由儿茶酚经环合而得。先将儿茶酚溶于二甲基亚砜（DMSO）中，再将氢氧化钠溶于剩余的二甲基亚砜中，并加入二氯甲烷，搅拌、加热回流，待温度升至95℃时，滴加儿茶酚二甲基亚砜溶液，保持回流温度在95-110℃。滴加完毕，在110-115℃保温搅拌1h。然后于130℃进行水蒸气蒸馏，98℃以下的低沸点馏分供下批套用，收集98-110℃正馏分，静置后分出油层，即得胡椒环，收率85%

1,2-亚甲二氧基苯海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,2-亚甲二氧基苯文献

Smooth photocatalytic preparation of 2-substituted 1,3-benzodioxoles.

Chemistry 17(2) , 572-9, (2011)

A mild and general method for the synthesis of potentially bioactive 2-substituted-1,3-benzodioxoles is presented. This is based on the photocatalyzed activation of methylene hydrogen atoms in the pre...

Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501.

Toxicol. Lett. 76(1) , 39-45, (1995)

A quantitative structure-activity relationship (QSAR) in a homologous series of alkoxy methylenedioxybenzenes (MDBs) is reported. Measurements of molecular dimensions from computer-generated space-fil...

Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring.

Eur. J. Med. Chem. 38(1) , 65-74, (2003)

Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic ...

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