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2,4-二氯-5-磺酰胺基苯甲酸

2,4-二氯-5-磺酰胺基苯甲酸用途

【用途一】
用于合成呋噻咪、速尿等药物
【用途二】
速尿的中间体。

2,4-二氯-5-磺酰胺基苯甲酸名称

[ CAS 号 ]:
2736-23-4

[ 中文名 ]:
2,4-二氯-5-磺酰胺基苯甲酸

[ 英文名 ]:
2,4-Dichloro-5-sulfamoylbenzoic acid

[中文别名 ]:

[英文别名 ]:

Benzoic acid,5-(aminosulfonyl)-2,4-dichloro
Benzoic acid, 5-(aminosulfonyl)-2,4-dichloro-
MFCD00007931
EINECS 220-358-3
5-(Aminosulfonyl)-2,4-dichlorobenzoic Acid
2,4-Dichloro-5-sulphamoylbenzoic acid
2,4-dichloro-5-sulfamoyl-benzoic acid
3-Sulfamoyl-4,6-dichlorobenzoic acid
2,4,5-TRICHLORO-N-(2-PHENOXYPROPYL)ANILINE
2,4-Dichloro-5-sulfamoylbenzoic acid

2,4-二氯-5-磺酰胺基苯甲酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
503.8±60.0 °C at 760 mmHg

[ 熔点 ]:
230-232 °C (dec.)(lit.)

[ 分子式 ]:
C₇H₅Cl₂NO₄S

[ 分子量 ]:
270.090

[ 闪点 ]:
258.5±32.9 °C

[ 精确质量 ]:
268.931641

[ PSA ]:
105.84000

[ LogP ]:
0.99

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.631

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
insoluble

2,4-二氯-5-磺酰胺基苯甲酸MSDS

详细MSDS(安全技术说明书)

2,4-二氯-5-磺酰胺基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG8100000

CHEMICAL NAME :: Benzoic acid, 2,4-dichloro-5-sulfamoyl-

CAS REGISTRY NUMBER :: 2736-23-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H5-Cl2-N-O4-S

MOLECULAR WEIGHT :: 270.09

WISWESSER LINE NOTATION :: ZSWR BG DG EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 19,697,1985

2,4-二氯-5-磺酰胺基苯甲酸安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ WGK德国 ]:
3

[ RTECS号 ]:
DG8100000

[ 海关编码 ]:
2935009090

2,4-二氯-5-磺酰胺基苯甲酸合成路线

详细合成路线

2,4-二氯-5-磺酰胺基苯甲酸上下游产品

2,4-二氯-5-磺酰胺基苯甲酸上游产品

2,4-二氯-5-磺酰胺基苯甲酸下游产品

2,4-二氯-5-磺酰胺基苯甲酸制备

用2，4-二氯苯甲酸以氯磺酸氯磺化，生成2，4-二氯-5-羧基苯磺酰氯，再以氨水胺化制得。

2,4-二氯-5-磺酰胺基苯甲酸海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%