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15-乙酰氧基松油醇

15-乙酰氧基松油醇用途

15-acetoxyscirpenol,acetoxyscirpenol 霉菌毒素 (ASMs) 之一,通过激活 caspase-3 以外的其他 caspases,以剂量依赖性方式抑制Jurkat T 细胞生长,诱导细胞凋亡。

15-乙酰氧基松油醇名称

[ CAS 号 ]:
2623-22-5

[ 中文名 ]:
15-乙酰蛇形菌素

[ 英文名 ]:
15-Acetoxyscirpenol

[英文别名 ]:

15-MONOACETOXYSCIRPENOL
deacetylanguidin
15-MONOACETYLSCIRPENOL
15-ACETOXYSCIRPENOL
15-Acetoxyscirpen-3,4-diol
monoacetoxyscirpenol
15-Acetoxyscirpenol
Desacetylanguidine
15-acetoxyscirpendiol
15-mas

15-乙酰氧基松油醇生物活性

[ 描述 ]:

15-acetoxyscirpenol,acetoxyscirpenol 霉菌毒素 (ASMs) 之一,通过激活 caspase-3 以外的其他 caspases,以剂量依赖性方式抑制Jurkat T 细胞生长,诱导细胞凋亡。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 其他

信号通路 >> 细胞凋亡 >> 胱天蛋白酶

[ 靶点 ]

Caspase

[参考文献]

[1]. Lee DH, et al. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54.

15-乙酰氧基松油醇物理化学性质

[ 密度 ]:
1.34g/cm3

[ 沸点 ]:
465.5ºC at 760mmHg

[ 熔点 ]:
170-172 °C

[ 分子式 ]:
C₁₇H₂₄O₅

[ 分子量 ]:
324.36900

[ 闪点 ]:
167.3ºC

[ 精确质量 ]:
324.15700

[ PSA ]:
88.52000

[ LogP ]:
0.55410

[ 蒸汽压 ]:
1.27E-10mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
-20°C

15-乙酰氧基松油醇MSDS

详细MSDS(安全技术说明书)

15-乙酰氧基松油醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0111000

CHEMICAL NAME :: Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15-acetate

CAS REGISTRY NUMBER :: 2623-22-5

LAST UPDATED :: 198709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H24-O6

MOLECULAR WEIGHT :: 324.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 725 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

15-乙酰氧基松油醇安全信息

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
R25

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

15-乙酰氧基松油醇

15-乙酰氧基松油醇用途

15-乙酰氧基松油醇名称

15-乙酰氧基松油醇生物活性

15-乙酰氧基松油醇物理化学性质

15-乙酰氧基松油醇MSDS

详细MSDS(安全技术说明书)

15-乙酰氧基松油醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

15-乙酰氧基松油醇安全信息

15-乙酰氧基松油醇合成路线

详细合成路线

15-乙酰氧基松油醇上下游产品

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