羟基马桑毒内酯
羟基马桑毒内酯名称
羟基马桑毒内酯物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
550.9±50.0 °C at 760 mmHg
[ 熔点 ]:
209-212°; mp 204-205° (Wakamatsu)
[ 分子式 ]:
C15H18O6
[ 分子量 ]:
294.300
[ 闪点 ]:
212.6±23.6 °C
[ 精确质量 ]:
294.110352
[ PSA ]:
91.82000
[ LogP ]:
1.38
[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C
[ 折射率 ]:
1.637
羟基马桑毒内酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WH1314800
- CHEMICAL NAME :
- Spiro(2,5-methano-7H-oxireno(3,4)cyclopent(1,2-d)oxep in-7,2'-oxiran)-3(2ah )-one, 1a-beta, 1b,5a,6,6a,7a-beta-hexahydro-1b-alpha,6-beta-dihydrox y-8a-isopropenyl-6a-a lpha-methyl-
- CAS REGISTRY NUMBER :
- 2571-22-4
- LAST UPDATED :
- 199007
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C15-H18-O6
- MOLECULAR WEIGHT :
- 294.33
- WISWESSER LINE NOTATION :
- T D3 C565 A EO GX KOVTJ AY1&U1 CQ H1 IQ G-& BT3OX CHJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,729,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3613 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 29,2,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1521 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 29,2,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1244 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 29,2,1940
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1666 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 2,73,1910
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 2,73,1910
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