2571-22-4

• 常用中文名：羟基马桑毒内酯
• 常用英文名：Tutin
• CAS号：2571-22-4
• 分子式：C₁₅H₁₈O₆
• 分子量：294.300
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-08-04 19:52:46
• 更新时间：2024-01-11 20:37:55

名称

• 中文名: 羟基马桑毒内酯
• 英文名: Tutin
• 中文别名: 羟基马桑内酯
• 英文别名: (1S,2R,3S,5R,6R,7R,8S,9R,12R)-2,8-Dihydroxy-12-isopropenyl-7-methyl-11H-spiro[4,10-dioxatetracyclo[7.2.1.0.0]dodecane-6,2'-oxiran]-11-one; Toot poison; [1aS-(1aa,1bb,2b,5b,6a,6ab,7b,7aa,8S*)]-Hexahydro-1b,6-dihydroxy-6a-methyl-8-(1-methylethenyl)spiro(2,5-methano-7H-oxireno[3,4]cyclopent[1,2-d]oxepin-7,2'-oxiran)-3(2H)-one; (1aS,1bR,2S,5R,6S,6aR,7R,7aR,8R)-1b,6-dihydroxy-6a-methyl-8-(prop-1-en-2-yl)hexahydrospiro[2,5-methanooxireno[3,4]cyclopenta[1,2-d]oxepine-7,2'-oxiran]-3(2H)-one; Tutu; (1S,2R,3S,5R,6R,7R,8S,9R,12R)-2,8-Dihydroxy-7-methyl-12-(prop-1-en-2-yl)-11H-spiro[4,10-dioxatetracyclo[7.2.1.0.0]dodecane-6,2'-oxiran]-11-one

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 550.9±50.0 °C at 760 mmHg
• 熔点: 209-212°; mp 204-205° (Wakamatsu)
• 分子式: C₁₅H₁₈O₆
• 分子量: 294.300
• 闪点: 212.6±23.6 °C
• 精确质量: 294.110352
• PSA: 91.82000
• LogP: 1.38
• 蒸汽压: 0.0±3.4 mmHg at 25°C
• 折射率: 1.637

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WH1314800 CHEMICAL NAME : Spiro(2,5-methano-7H-oxireno(3,4)cyclopent(1,2-d)oxep in-7,2'-oxiran)-3(2ah )-one, 1a-beta, 1b,5a,6,6a,7a-beta-hexahydro-1b-alpha,6-beta-dihydrox y-8a-isopropenyl-6a-a lpha-methyl- CAS REGISTRY NUMBER : 2571-22-4 LAST UPDATED : 199007 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C15-H18-O6 MOLECULAR WEIGHT : 294.33 WISWESSER LINE NOTATION : T D3 C565 A EO GX KOVTJ AY1&U1 CQ H1 IQ G-& BT3OX CHJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,729,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3613 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 29,2,1940 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1521 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 29,2,1940 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1244 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 29,2,1940 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1666 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 2,73,1910 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 2,73,1910