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5′-脱氧-5′-(甲硫基)腺苷

5′-脱氧-5′-(甲硫基)腺苷用途

5'-Methylthioadenosine 是由 S-腺苷酸产生的,有强效的抑制作用。

5′-脱氧-5′-(甲硫基)腺苷名称

[ CAS 号 ]:
2457-80-9

[ 中文名 ]:
甲硫腺苷

[ 英文名 ]:
Adenylthiomethylpentose

[中文别名 ]:

[英文别名 ]:

5-Methylthioadenosine
Vitamin L2
5'-S-Methylthioadenosine
5'-S-Methyl-5'-thioadenosine
Adenosine, 5'-S-methyl-5'-thio-
5'-Deoxy-5'-(methylthio)adenosine
MFCD00010533
MTA,Methylthioadenosine
5'-Deoxy-5'-Methylthioadenosine
Adenylthiomethylpentose

5′-脱氧-5′-(甲硫基)腺苷生物活性

[ 描述 ]:

5'-Methylthioadenosine 是由 S-腺苷酸产生的,有强效的抑制作用。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

5'-甲硫腺苷(MTA)可以多种方式影响细胞过程。已显示5'-甲硫腺苷影响细胞的许多关键反应,包括基因表达,增殖,分化和凋亡的调节。尽管大多数这些反应已在药理学水平上观察到,但它们的特异性使得推测内源性5'-甲硫腺苷可能在细胞中起调节作用是诱人的。最后,在肝损伤和癌症模型中进行的观察证明了5'-甲硫腺苷的治疗潜力值得进一步考虑[1]。

[参考文献]

[1]. Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30.

[相关活性小分子]

5′-脱氧-5′-(甲硫基)腺苷物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
642.7±65.0 °C at 760 mmHg

[ 熔点 ]:
210-213ºC (dec.)

[ 分子式 ]:
C₁₁H₁₅N₅O₃S

[ 分子量 ]:
297.333

[ 闪点 ]:
342.5±34.3 °C

[ 精确质量 ]:
297.089569

[ PSA ]:
144.61000

[ LogP ]:
0.67

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.843

[ 储存条件 ]:
−20°C

5′-脱氧-5′-(甲硫基)腺苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7410000

CHEMICAL NAME :: Adenosine, 5'-S-methyl-5'-thio-

CAS REGISTRY NUMBER :: 2457-80-9

BEILSTEIN REFERENCE NO. :: 0042420

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H15-N5-O3-S

MOLECULAR WEIGHT :: 297.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 100 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,653,1987

5′-脱氧-5′-(甲硫基)腺苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU7410000

[ 海关编码 ]:
2934999090

5′-脱氧-5′-(甲硫基)腺苷上下游产品

5′-脱氧-5′-(甲硫基)腺苷上游产品

5′-脱氧-5′-(甲硫基)腺苷下游产品

5′-脱氧-5′-(甲硫基)腺苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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