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丙戊酰胺

丙戊酰胺用途

抗癫痫药，用于多种类型癫痫的治疗与预防

丙戊酰胺名称

[ CAS 号 ]:
2430-27-5

[ 中文名 ]:
丙戊酰胺

[ 英文名 ]:
Valpromide

[中文别名 ]:

[英文别名 ]:

Depamide
2-Propylvaleramide
Valpromide
2,2-Di-n-propylacetamide
Pentanamide,2-propyl
EINECS 219-394-2
MFCD00051534
2-Ethylvaleramide
2-propylpentamide
2,2-BIS(TRIFLUOROMETHYL)PROPANOL

丙戊酰胺生物活性

[ 描述 ]:

Valpromide 是丙戊酸的酰胺衍生物,可抑制人类环氧化物水解酶。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 感染

研究领域 >> 神经疾病

[ 靶点 ]

epoxide hydrolase[1]

[参考文献]

[1]. Pacifici GM, et al. Valpromide inhibits human epoxide hydrolase. Br J Clin Pharmacol. 1986 Sep;22(3):269-74.

[2]. Gorres KL, et al. Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus. MBio. 2016 Mar 1;7(2):e00113.

[相关活性小分子]

丙戊酰胺物理化学性质

[ 密度 ]:
0.885g/cm3

[ 沸点 ]:
274.6ºC at 760mmHg

[ 熔点 ]:
123-125°C

[ 分子式 ]:
C₈H₁₇NO

[ 分子量 ]:
143.22700

[ 闪点 ]:
119.9ºC

[ 精确质量 ]:
143.13100

[ PSA ]:
43.09000

[ LogP ]:
2.38840

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.00535mmHg at 25°C

[ 折射率 ]:
1.44

[ 储存条件 ]:
room temp

丙戊酰胺MSDS

详细MSDS(安全技术说明书)

丙戊酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV5965500

CHEMICAL NAME :: Valeramide, 2-propyl-

CAS REGISTRY NUMBER :: 2430-27-5

BEILSTEIN REFERENCE NO. :: 1750444

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H17-N-O

MOLECULAR WEIGHT :: 143.26

WISWESSER LINE NOTATION :: ZVY3&3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 890 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GNAW "Pharmacodynamie de l'Acide Dipropylacetique (ou Propyl-2-Pentanoique) et de ses Amides," Carraz, G., Imprimerie Eymond, 1968 Volume(issue)/page/year: -,72,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GNAW "Pharmacodynamie de l'Acide Dipropylacetique (ou Propyl-2-Pentanoique) et de ses Amides," Carraz, G., Imprimerie Eymond, 1968 Volume(issue)/page/year: -,71,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 438 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 9,37,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,669,1986

丙戊酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
YV5965500

[ 海关编码 ]:
2924199090

丙戊酰胺制备

由氰基乙酸甲酯经烷基化得到a-氰基正丙基戊酸甲酯，经水解、脱羧再水解而得。

丙戊酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

丙戊酰胺文献

The synergistic effects of DNA-damaging drugs cisplatin and etoposide with a histone deacetylase inhibitor valproate in high-risk neuroblastoma cells.

Int. J. Oncol. 47 , 343-52, (2015)

High-risk neuroblastoma remains one of the most important therapeutic challenges for pediatric oncologists. New agents or regimens are urgently needed to improve the treatment outcome of this fatal tu...

Amidic modification of valproic acid reduces skeletal teratogenicity in mice.

Birth Defects Res. B Dev. Reprod. Toxicol. 71(1) , 47-53, (2004)

The antiepileptic drug valproic acid (VPA) is well known to cause neural tube and skeletal defects in both humans and animals. The amidic VPA analogues valpromide (VPD) and valnoctamide (VCD) have muc...

Polycomb homologs are involved in teratogenicity of valproic acid in mice.

Birth Defects Res. A Clin. Mol. Teratol. 70(11) , 870-9, (2004)

Valproic acid (VPA) is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its teratogenic mechanisms are unknown. We have attempted to describe a fundamental role o...

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