密旋霉素

密旋霉素用途

Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act

密旋霉素名称

[ CAS 号 ]:
23668-11-3

[ 中文名 ]:
密旋霉素

[ 英文名 ]:
Pactamycin

[英文别名 ]:

Pactamycin

密旋霉素物理化学性质

[ 密度 ]:
1.38g/cm3

[ 沸点 ]:
784.2ºC at 760mmHg

[ 分子式 ]:
C₂₈H₃₈N₄O₈

[ 分子量 ]:
558.62300

[ 闪点 ]:
428.1ºC

[ 精确质量 ]:
558.26900

[ PSA ]:
194.68000

[ LogP ]:
1.91870

[ 蒸汽压 ]:
6.66E-26mmHg at 25°C

[ 折射率 ]:
1.645

密旋霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT0790000

CHEMICAL NAME :: Pactamycin

CAS REGISTRY NUMBER :: 23668-11-3

LAST UPDATED :: 199504

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C28-H38-N4-O8

MOLECULAR WEIGHT :: 558.70

WISWESSER LINE NOTATION :: L5TJ AYQ1 AMVN1&1 BQ B1OVR CQ F1& CQ C1 DMR CV1& EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 ug/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - other changes Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15600 ug/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - other changes Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 750 ug/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - other changes Liver - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 6 mg/kg

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 11,311,1975 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

密旋霉素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H315-H319-H335

[ 警示性声明 ]:
P261-P264-P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGII

密旋霉素文献

Enantioselective synthesis of pactamycin, a complex antitumor antibiotic.

Science 340(6129) , 180-2, (2013)

Medicinal application of many complex natural products is precluded by the impracticality of their chemical synthesis. Pactamycin, the most structurally intricate aminocyclopentitol antibiotic, displa...

Total synthesis of pactamycin and pactamycate: a detailed account.

J. Org. Chem. 77(21) , 9458-72, (2012)

This article describes synthetic studies that culminated in the first total synthesis of pactamycin and pactamycate and, in parallel, the two known congeners, de-6-MSA-pactamycin and de-6-MSA-pactamyc...

Diastereocontrolled construction of pactamycin's complex ureido triol functional array.

Org. Lett. 14(11) , 2878-81, (2012)

An advanced intermediate in a projected synthesis of pactamycin has been prepared. Early installation of the C1-dimethylurea functionality allows for its participation in a diastereoselective, chelati...

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